US 12,291,546 B2
Phosphonium compound, reagent kit for derivatization, mass spectrometric method, and method for producing phosphonium compound
Seketsu Fukuzawa, Tokyo (JP); Koji Takahashi, Tokyo (JP); Yoshiyuki Itoh, Tokyo (JP); Masaki Takiwaki, Tokyo (JP); Shugo Tsuda, Ibaraki (JP); Masayoshi Mochizuki, Ibaraki (JP); and Taku Yoshiya, Ibaraki (JP)
Assigned to JEOL Ltd., Tokyo (JP)
Filed by JEOL Ltd., Tokyo (JP)
Filed on Oct. 6, 2022, as Appl. No. 17/961,020.
Claims priority of application No. 2021-165739 (JP), filed on Oct. 7, 2021.
Prior Publication US 2023/0112623 A1, Apr. 13, 2023
Int. Cl. C07F 9/54 (2006.01)
CPC C07F 9/54 (2013.01) [C07B 2200/13 (2013.01)] 5 Claims
 
1. A phosphonium compound represented by Formula (I):

OG Complex Work Unit Chemistry
wherein in Formula (I),
R1 is an alkyl group, the alkyl group being a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms; and
R2 and R3 are independently from each other, an alkyl group or an aryl group,
the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, and
the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms;
wherein X is a group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group, and
when X is the group having the hydrazide group, the group is

OG Complex Work Unit Chemistry
wherein o is any integer of 0 to 6;
when X is the group having the halide group or the pseudohalide group, the group is

OG Complex Work Unit Chemistry
wherein W is a halogen or a pseudohalogen, and p is any integer of 0 to 6; or
when X is the group having the thioester group, the group is

OG Complex Work Unit Chemistry
wherein V is H, NH2, a sulfonate ion group SO3−, SO3M, COO−, or COOM, and M is a hydrogen atom, a lithium atom, a sodium atom, or a potassium atom; and
Y− is an anion having a total charge of −1, or Y− is absence.