US 12,291,518 B2
Thyroid hormone receptor agonists and use thereof
Jingye Zhou, Shanghai (CN); Jiuxiang Zhu, Shanghai (CN); and Mingwei Zheng, Shanghai (CN)
Assigned to Eccogene Inc., Cambridge, MA (US)
Filed by Eccogene Inc., Cambridge, MA (US)
Filed on Aug. 11, 2023, as Appl. No. 18/448,277.
Application 18/448,277 is a continuation of application No. 17/147,538, filed on Jan. 13, 2021, granted, now 11,780,825.
Claims priority of application No. PCT/CN2020/071741 (WO), filed on Jan. 13, 2020; and application No. PCT/CN2020/107757 (WO), filed on Aug. 7, 2020.
Prior Publication US 2024/0190846 A1, Jun. 13, 2024
Int. Cl. C07D 403/12 (2006.01); C07D 253/075 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 471/08 (2006.01)
CPC C07D 403/12 (2013.01) [C07D 253/075 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 471/08 (2013.01)] 4 Claims
 
1. A pharmaceutical composition comprising a compound selected from the table below:
 
Structure Chemical Name
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxybenzamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1,3r)-3- hydroxycyclobutyl)benzamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(3,5-dioxo-6- (trifluoromethyl)-4,5-dihydro-1,2,4-triazin- 2(3H)-yl)phenoxy)-N-(3,3- difluorocyclobutyl)-2-hydroxybenzamide,
 
 

OG Complex Work Unit Chemistry
 N-(tert-butyl)-5-(2,6-dichloro-4-(3,5-dioxo- 6-(trifluoromethyl)-4,5-dihydro-1,2,4-triazin- 2(3H)-yl)phenoxy)-2-hydroxybenzamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-5-(2,6-dichloro-4-(3,5-dioxo-6- (trifluoromethyl)-4,5-dihydro-1,2,4-triazin- 2(3H)-yl)phenoxy)-2-hydroxybenzamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(3,5,7- trifluoroadamantan-1-yl)benzamide,
 
 

OG Complex Work Unit Chemistry
 2-(4-(3-((1R,4S)-2-azabicyclo[2.2.1]heptane- 2-carbonyl)-4-hydroxyphenoxy)-3,5- dichlorophenyl)-6-chloro-1,2,4-triazine- 3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 2-(4-(3-((1S,4R)-2-azabicyclo[2.2.1]heptane- 2-carbonyl)-4-hydroxyphenoxy)-3,5- dichlorophenyl)-6-chloro-1,2,4-triazine- 3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((3-cyclobutyl-4- hydroxyphenyl)sulfonyl)phenyl)-6- (trifluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-5-(2,6-dichloro-4-(3,5-dioxo-6- (trifluoromethyl)-4,5-dihydro-1,2,4-triazin- 2(3H)-yl)phenoxy)-4-fluoro-2- hydroxybenzamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-4-fluoro-2- hydroxybenzamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N- methylbenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(4-hydroxy-3- (morpholinosulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(4-hydroxy-3-((4- hydroxypiperidin-1- yl)sulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 N-(1-cyanocyclopropyl)-5-(2,6-dichloro-4- (6-(difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (1r,3r)-N-cyclopropyl-3-((5-(2,6-dichloro-4- (6-(difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclobutane-1- carboxamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-5-(2,6-dichloro-4-(3,5-dioxo- 6-(trifluoromethyl)-4,5-dihydro-1,2,4-triazin- 2(3H)-yl)phenoxy)-2- hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(3,5-dioxo-6- (trifluoromethyl)-4,5-dihydro-1,2,4-triazin- 2(3H)-yl)phenoxy)-2-hydroxy-N- methylbenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(3-((4,4-difluoropiperidin- 1-yl)sulfonyl)-4-hydroxyphenoxy)phenyl)-6- (trifluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 1-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxyphenyl)sulfonamido)- N-methylcyclopropane-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 1-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclopropane- 1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 1-((5-(2,6-dichloro-4-(3,5-dioxo-6- (trifluoromethyl)-4,5-dihydro-1,2,4-triazin- 2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)-N- methylcyclopropane-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 N-((1r,3r)-3-cyanocyclobutyl)-5-(2,6- dichloro-4-(6-(difluoromethyl)-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)- 2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(3-((4,4-difluoropiperidin- 1-yl)sulfonyl)-4-hydroxyphenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(4-(3-(azetidin-1-ylsulfonyl)-4- hydroxyphenoxy)-3,5-dichlorophenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 (S)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(tetrahydrofuran- 3-yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(tetrahydrofuran- 3-yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(4-hydroxy-3-(piperazin-1- ylsulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(3-((4- (cyclopropanecarbonyl)piperazin-1- yl)sulfonyl)-4-hydroxyphenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(4-hydroxy-3-((4-methyl- 3-oxopiperazin-1- yl)sulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 (S)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1-methyl-5- oxopyrrolidin-3-yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1-methyl-5- oxopyrrolidin-3-yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1r,3r)-3- methoxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1s,3s)-3- methoxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-(1-(azetidine-1-carbonyl)cyclopropyl)-5- (2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-2-(3,5-dichloro-4-(4-hydroxy-3-((3- (methylsulfonyl)pyrrolidin-1- yl)sulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(4-hydroxy-3-((3- hydroxyazetidin-1- yl)sulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 (S)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1- hydroxypropan-2-yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(((1r,3r)-3- hydroxycyclobutyl)methyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(((1s,3s)-3- hydroxycyclobutyl)methyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1- hydroxypropan-2-yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-N-(1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonyl)pyrrolidin-3- yl)methanesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-N-(1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonyl)pyrrolidin-3- yl)methanesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-N-(1-(cyclopropylsulfonyl)pyrrolidin-3- yl)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-N-(1-(cyclopropylsulfonyl)pyrrolidin-3- yl)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1- (methylsulfonyl)pyrrolidin-3- yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1- (methylsulfonyl)pyrrolidin-3- yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-(1-(cyclopropanecarbonyl)azetidin-3-yl)- 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 3-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxyphenyl)sulfonamido)- N,N-dimethylazetidine-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1- (methylsulfonyl)azetidin-3- yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-N-(1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonyl)pyrrolidin-3- yl)ethanesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-N-(1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonyl)pyrrolidin-3- yl)cyclopropanecarboxamide,
 
 

OG Complex Work Unit Chemistry
 3-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxyphenyl)sulfonamido)- N-methylazetidine-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 2-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2- hydroxyphenyl)sulfonamido)acetamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-2-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)acetamide,
 
 

OG Complex Work Unit Chemistry
 2-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxyphenyl)sulfonamido)- N-methylacetamide,
 
 

OG Complex Work Unit Chemistry
 (1r,3r)-3-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)-N- methylcyclobutane-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-2-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)acetamide,
 
 

OG Complex Work Unit Chemistry
 N-(2-(azetidin-1-yl)-2-oxoethyl)-5-(2,6- dichloro-4-(6-(difluoromethyl)-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)- 2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxypyridine-3-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(2- methoxyethyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1R,3S)-3- hydroxycyclopentyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1S,3R)-3- hydroxycyclopentyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-((1s,3s)-3-cyanocyclobutyl)-5-(2,6- dichloro-4-(6-(difluoromethyl)-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)- 2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1- (hydroxymethyl)cyclopropyl)benzene- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclopropane- 1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-methylpyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-(1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonyl)azetidin-3- yl)methanesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(6- hydroxyspiro[3.3]heptan-2- yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1R,3R)-3- hydroxycyclopentyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-2-(3,5-dichloro-4-(4-hydroxy-3-((3- hydroxypyrrolidin-1- yl)sulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 (S)-2-(3,5-dichloro-4-(4-hydroxy-3-((3- hydroxypyrrolidin-1- yl)sulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 N-((1r,3r)-3-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclobutyl) cyclopropanecarboxamide,
 
 

OG Complex Work Unit Chemistry
 N-(3-cyanobicyclo[1.1.1]pentan-1-yl)-5- (2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1- hydroxycyclopropyl)methyl)benzene- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(3- hydroxybicyclo[1.1.1]pentan-1- yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1r,3r)-3- (methylsulfonyl)cyclobutyl)benzene- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-N-(1,1-dioxidothietan-3-yl)-2- hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-((1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclopropyl) methyl)cyclopropanecarboxamide,
 
 

OG Complex Work Unit Chemistry
 N-(3-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)bicyclo[1.1.1] pentan-1-yl)cyclopropanecarboxamide,
 
 

OG Complex Work Unit Chemistry
 N-((1s,3s)-3-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclobutyl) cyclopropanecarboxamide,
 
 

OG Complex Work Unit Chemistry
 1-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxyphenyl)sulfonamido)- N-(2,2-difluoroethyl)cyclopropane-1- carboxamide,
 
 

OG Complex Work Unit Chemistry
 2-((5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxyphenyl)sulfonamido)- N-(2,2-difluoroethyl)acetamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclopropane- 1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopentyl-1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclopropane- 1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1-(pyrrolidine-1- carbonyl)cyclopropyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-1-((5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclobutane-1- carboxamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-1-((5-(2,6-dichloro-4-(3,5- dioxo-6-(trifluoromethyl)-4,5-dihydro-1,2,4- triazin-2(3H)-yl)phenoxy)-2- hydroxyphenyl)sulfonamido)cyclopropane- 1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1- ((methylsulfonyl)methyl)cyclopropyl) benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(4-hydroxy-3- (methylsulfonyl)phenoxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(1-oxidothietan-3- yl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)benzyl)-2-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-5-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-(tetrahydrofuran- 3-yl)benzamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)-N- methylbenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-(4-hydroxy-3-(((1s,3s)-3- hydroxycyclobutyl)sulfonyl)phenoxy)phenyl)- 6-(difluoromethyl)-1,2,4-triazine- 3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 N-((1-((2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine)-4- sulfonamido)cyclopropyl)methyl) cyclopropanecarboxamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-cyano-3,5-dioxo-4,5- dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxy-N-methylpyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(1- (methoxymethyl)cyclopropyl)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-2-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(tetrahydrofuran- 3-yl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-N-(3,3-difluorocyclobutyl)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-2-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(tetrahydrofuran- 3-yl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((5-hydroxy-4-((3- hydroxyazetidin-1-yl)sulfonyl)pyridin-2- yl)oxy)phenyl)-6-(difluoromethyl)-1,2,4- triazine-3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 (S)-2-(3,5-dichloro-4-((5-hydroxy-4-((3- hydroxypyrrolidin-1-yl)sulfonyl)pyridin-2- yl)oxy)phenyl)-6-(difluoromethyl)-1,2,4- triazine-3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((4-((3,3-difluoroazetidin- 1-yl)sulfonyl)-5-hydroxypyridin-2- yl)oxy)phenyl)-6-(difluoromethyl)-1,2,4- triazine-3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-isopropylpyridine- 4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-N-(2,2-difluoroethyl)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-N-ethyl-5-hydroxypyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N,N- dimethylpyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-2-(2,6-dichloro-4-(6-cyano- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxypyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-1-((2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine)-4- sulfonamido)cyclopropane-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopentyl-1-((2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine)-4- sulfonamido)cyclopropane-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 1-((2-(2,6-dichloro-4-(6-(difluoromethyl)- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxypyridine)-4- sulfonamido)-N-(2,2- difluoroethyl)cyclopropane-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(1-(pyrrolidine-1- carbonyl)cyclopropyl)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-2-((2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine)-4-sulfonamido)acetamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-2-((2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine)-4-sulfonamido)acetamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-1-((2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine)-4- sulfonamido)cyclobutane-1-carboxamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-N-(3,3-dimethylcyclobutyl)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopentyl-2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-((1s,3s)-3-cyanocyclobutyl)-2-(2,6- dichloro-4-(6-(difluoromethyl)-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)- 5-hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-methoxy-N-methylpyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((4-(cyclopropylsulfonyl)- 5-hydroxypyridin-2-yl)oxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((4-(cyclopropylsulfonyl)- 5-hydroxypyridin-2-yl)oxy)phenyl)-3,5- dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6- carbonitrile,
 
 

OG Complex Work Unit Chemistry
 N-((1r,3r)-3-cyanocyclobutyl)-2-(2,6- dichloro-4-(6-(difluoromethyl)-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)- 5-hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclopropyl-2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(((1r,3r)-3- hydroxycyclobutyl)methyl)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(((1s,3s)-3- hydroxycyclobutyl)methyl)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-(1-cyanocyclopropyl)-2-(2,6-dichloro-4- (6-(difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(tetrahydro-2H- pyran-4-yl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(2-hydroxy-2- methylpropyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1s,3s)-3- hydroxy-3-methylcyclobutyl)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1r,3r)-3- methoxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1s,3s)-3- methoxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-2-(3,5-dichloro-4-((5-hydroxy-4-((3- hydroxypyrrolidin-1-yl)sulfonyl)pyridin-2- yl)oxy)phenyl)-6-(difluoromethyl)-1,2,4- triazine-3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(3- hydroxybicyclo[1.1.1]pentan-1-yl)pyridine- 4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1r,4r)-4- hydroxycyclohexyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1s,4s)-4- hydroxycyclohexyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxyisonicotinamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((5-hydroxy-4- (methylsulfonyl)pyridin-2-yl)oxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((5-hydroxy-4- (methylsulfonyl)pyridin-2-yl)oxy)phenyl)- 3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6- carbonitrile,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-N-(1,1-dioxidothietan-3-yl)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 4-cyano-5-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-2-hydroxy- N-((1r,3r)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-2-(2,6-dichloro-4-(6-cyano- 3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxypyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((4-(ethylsulfonyl)-5- hydroxypyridin-2-yl)oxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)benzyl)-N-(1,1-dioxidothietan-3-yl)-2- hydroxybenzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((4-(cyclobutylsulfonyl)-5- hydroxypyridin-2-yl)oxy)phenyl)-6- (difluoromethyl)-1,2,4-triazine-3,5(2H,4H)- dione,
 
 

OG Complex Work Unit Chemistry
 2-(3,5-dichloro-4-((5-hydroxy-4- ((methylsulfonyl)methyl)pyridin-2- yl)oxy)phenyl)-6-(difluoromethyl)-1,2,4- triazine-3,5(2H,4H)-dione,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)benzyl)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(oxetan-3- yl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(4- hydroxybicyclo[2.1.1]hexan-1-yl)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(4- hydroxybicyclo[2.2.1]heptan-1-yl)pyridine- 4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-methyl-3,5-dioxo-4,5- dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-methyl-3,5-dioxo-4,5- dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxy-N-((1s,3s)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 (R)-2-(2,6-dichloro-4-(6-methyl-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)- 5-hydroxy-N-(tetrahydrofuran-3-yl)pyridine- 4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 (S)-2-(2,6-dichloro-4-(6-methyl-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)- 5-hydroxy-N-(tetrahydrofuran-3-yl)pyridine- 4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5-hydroxy- N-((1r,3r)-3-hydroxycyclobutyl)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(4-(6-(difluoromethyl)-3,5-dioxo-4,5- dihydro-1,2,4-triazin-2(3H)-yl)-2,6- dimethylphenoxy)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2-chloro-4-(6-(difluoromethyl)-3,5-dioxo- 4,5-dihydro-1,2,4-triazin-2(3H)-yl)-6- methylphenoxy)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-[2,6-dichloro-4-[6-(difluoromethyl)-3,5- dioxo-1,2,4-triazin-2-yl]phenoxy]-5- hydroxy-N-(3-hydroxy-1-methyl- cyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-(1-methylazetidin- 3-yl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-[2,6-dichloro-4-[6-(difluoromethyl)-3,5- dioxo-1,2,4-triazin-2-yl]phenoxy]-5- hydroxy-N-[(1R,2S)-2- hydroxycyclobutyl]pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-[2,6-dichloro-4-[6-(difluoromethyl)-3,5- dioxo-1,2,4-triazin-2-yl]phenoxy]-5- hydroxy-N-[(1R,2R)-2- hydroxycyclobutyl]pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-3-fluoro-5-hydroxy-N-((1r,3r)- 3-hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl-3-d)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl-1-d)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy-3,5-d2)-2-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl-d)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl-3-d)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl-1-d)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy-3,5-d2)-2-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 5-(2,6-dichloro-4-(6-(difluoromethyl-d)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-2-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl)benzenesulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl-3-d)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl-1-d)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy-3,5-d2)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl-d)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1r,3r)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl-3-d)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl-1-d)pyridine-4- sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy-3,5-d2)-5-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 2-(2,6-dichloro-4-(6-(difluoromethyl-d)-3,5- dioxo-4,5-dihydro-1,2,4-triazin-2(3H)- yl)phenoxy)-5-hydroxy-N-((1s,3s)-3- hydroxycyclobutyl)pyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-(cyclobutyl-3,3-d2)-2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine-4-sulfonamide,
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-2-(2,6-dichloro-4-(6- (difluoromethyl)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy-3,5-d2)-5- hydroxypyridine-4-sulfonamide, and
 
 

OG Complex Work Unit Chemistry
 N-cyclobutyl-2-(2,6-dichloro-4-(6- (difluoromethyl-d)-3,5-dioxo-4,5-dihydro- 1,2,4-triazin-2(3H)-yl)phenoxy)-5- hydroxypyridine-4-sulfonamide,
 
or a pharmaceutically acceptable salt, solvate, prodrug, stereoisomer, or tautomer thereof, and a pharmaceutically acceptable diluent, excipient or carrier.