US 12,290,806 B2
Substrate with channels for controlled fluid flow
Samantha Chang, San Marcos, CA (US); Jason McClure, San Diego, CA (US); Robert Reed, Carlsbad, CA (US); Irene Sinn Blandy, San Diego, CA (US); Robert Weiller, Encinitas, CA (US); and Christian Bobritchi, San Diego, CA (US)
Assigned to Ortho-Clinical Diagnostics, Inc., Raritan, NJ (US)
Filed by Quidel Corporation, San Diego, CA (US)
Filed on Mar. 4, 2022, as Appl. No. 17/687,413.
Application 17/687,413 is a continuation of application No. 15/893,375, filed on Feb. 9, 2018, granted, now 11,446,654.
Claims priority of provisional application 62/598,947, filed on Dec. 14, 2017.
Claims priority of provisional application 62/472,182, filed on Mar. 16, 2017.
Claims priority of provisional application 62/457,660, filed on Feb. 10, 2017.
Prior Publication US 2022/0184605 A1, Jun. 16, 2022
Int. Cl. B01L 3/00 (2006.01); G01N 33/543 (2006.01); G01N 33/569 (2006.01)
CPC B01L 3/5023 (2013.01) [B01L 3/5027 (2013.01); G01N 33/54389 (2021.08); B01L 2300/0858 (2013.01); B01L 2300/0861 (2013.01); B01L 2400/082 (2013.01); G01N 33/569 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A device, comprising:
a laminated structure comprising a nitrocellulose substrate layer provided on a hydrophobic support layer,
a plurality of parallel fluid flow channels, each parallel fluid flow channel separated from an adjacent parallel fluid flow channel by a nitrocellulose substrate-devoid gap exposing the hydrophobic support layer, wherein each substrate-devoid gap forms a side channel that is essentially impermeable to flow of an aqueous fluid;
a single sample receiving zone positioned on the substrate to distribute a portion of a sample deposited thereon into each fluid flow channel in the plurality of parallel fluid flow channels;
a fluid control feature ablated or etched on a surface of the nitrocellulose substrate, the fluid control feature composed of a nitrocellulose substrate-devoid area exposing the hydrophobic support layer, wherein the fluid control feature is configured to guide the portion of sample into one or more of the parallel fluid flow channels; and
a capture zone in each of the plurality of fluid flow channels, wherein the capture zone comprises a reagent comprising a binding member.