US 12,290,762 B2
System for preparing solutions for chromatography
Bjorn Markus Olovsson, Uppsala (SE)
Assigned to Cytiva Sweden AB, Uppsala (SE)
Filed by Cytiva Sweden AB, Uppsala (SE)
Filed on Sep. 25, 2023, as Appl. No. 18/474,000.
Application 18/474,000 is a continuation of application No. 17/156,749, filed on Jan. 25, 2021, granted, now 11,801,456.
Application 17/156,749 is a continuation of application No. 15/533,405, granted, now 10,926,191, issued on Feb. 23, 2021, previously published as PCT/EP2015/079267, filed on Dec. 10, 2015.
Claims priority of application No. 1422107 (GB), filed on Dec. 12, 2014.
Prior Publication US 2024/0009594 A1, Jan. 11, 2024
Int. Cl. B01D 15/16 (2006.01); B01D 15/22 (2006.01); B01F 23/40 (2022.01); B01F 25/31 (2022.01); B01F 35/21 (2022.01); B01F 35/22 (2022.01); B01F 35/221 (2022.01); B01F 35/71 (2022.01); F04B 23/04 (2006.01); G01N 30/32 (2006.01); G01N 30/34 (2006.01); G01N 30/86 (2006.01)
CPC B01D 15/166 (2013.01) [B01D 15/22 (2013.01); B01F 23/49 (2022.01); B01F 25/31 (2022.01); B01F 35/2132 (2022.01); B01F 35/2133 (2022.01); B01F 35/2211 (2022.01); B01F 35/7176 (2022.01); F04B 23/04 (2013.01); G01N 30/32 (2013.01); G01N 30/34 (2013.01); B01D 15/16 (2013.01); G01N 2030/324 (2013.01); G01N 2030/347 (2013.01); G01N 30/8658 (2013.01)] 24 Claims
OG exemplary drawing
 
11. A chromatography system comprising:
at least one chromatography column;
a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution, wherein the T-joint receives the second solution from a solution supply unit connected to the T-joint, wherein the T-joint is connected to the solution supply unit using at least one direct connection tube, and wherein the T-joint is connected through at least one valve to a further solution supply unit for supplying the at least one first solution;
at least one low pressure pump for supplying the at least one first solution into the T-joint; and
a high pressure pump for collecting and delivering the buffer solution to the at least one chromatography column,
the chromatography system being characterized in that said T-joint includes a configuration for mixing the at least one first solution and the second solution, wherein the configuration for mixing the at least one first solution and the second solution is a magnetic stirrer,
wherein the system is configured such that the low-pressure pump, the T-joint, and the magnetic stirrer operate at a pressure of less than 0.7 mega Pascals (MPa).