| CPC A61N 5/1049 (2013.01) [G06T 7/0016 (2013.01); G06T 7/262 (2017.01); A61N 2005/1055 (2013.01); A61N 2005/1061 (2013.01); G06T 2207/10016 (2013.01); G06T 2207/10081 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/20084 (2013.01); G06T 2207/30004 (2013.01)] | 20 Claims |

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1. A method for estimating a patient state comprising:
receiving a 3D reference volume;
receiving a real-time stream of images from an image acquisition device;
using a hardware processor to implement a patient state generator network to:
encode the 3D reference volume using a 3D encoder branch of the patient state generator network;
encode the real-time stream of images using a 2D encoder branch of the patient state generator network;
combine the encoded 3D reference volume and the encoded real-time stream of images; and
estimate a 3D spatial transform that maps the 3D reference volume to a current patient state using a 3D decoder branch of the patient state generator network.
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