	US 12,290,654 B2
	Using alternating electric fields to increase permeability of the blood brain barrier
Carsten Hagemann, Unterpleichfeld (DE); Mario Lohr, Dillenburg (DE); Almuth F. Kessler, Reichenberg (DE); Malgorzata Burek, Wurzburg (DE); Carola Forster, Wurzburg (DE); Catherine Brami, Matan (IL); Hadas Sara Hershkovich, Kiryat Motzkin (IL); and Tali Voloshin-Sela, Haifa (IL)
Assigned to Novocure Gmbh, Baar (CH)
Filed by Novocure GmbH, Root (CH)
Filed on May 11, 2022, as Appl. No. 17/741,651.
Application 17/741,651 is a continuation of application No. 16/548,514, filed on Aug. 22, 2019, granted, now 11,351,349.
Claims priority of provisional application 62/722,100, filed on Aug. 23, 2018.
Prior Publication US 2022/0265982 A1, Aug. 25, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/32 (2006.01); A61K 9/00 (2006.01); A61M 37/00 (2006.01); A61N 1/36 (2006.01); A61N 1/372 (2006.01)

CPC A61M 37/0092 (2013.01) [A61K 9/0009 (2013.01); A61N 1/325 (2013.01); A61N 1/327 (2013.01); A61N 1/36002 (2017.08); A61N 1/3603 (2017.08); A61N 1/37217 (2013.01); A61K 9/0085 (2013.01); A61M 2037/0007 (2013.01); A61M 2202/0007 (2013.01); A61M 2210/0693 (2013.01); A61M 2250/00 (2013.01)]

12 Claims

1. A method for delivering a substance across a blood brain barrier of a subject's brain, the method comprising:

applying an alternating electric field at a first frequency to the subject's brain for a period of time, wherein the subject's brain is tumor-free, wherein the first frequency is between 50 kHz and 190 kHz, and wherein application of the alternating electric field at the first frequency to the subject's brain for the period of time increases permeability of the blood brain barrier in the subject's brain; and

administering the substance to the subject, wherein the increased permeability of the blood brain barrier allows the substance to cross the blood brain barrier,

wherein the period of time is at least 24 hours and the substance is administered to the subject after the period of time has elapsed.