US 12,290,653 B2
Microneedle sheet production method and microneedle sheet
Eisuke Hatanaka, Tsukuba (JP); Kazuki Kuriyama, Tsukuba (JP); and Naoki Yamamoto, Tsukuba (JP)
Assigned to HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
Appl. No. 16/973,553
Filed by HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
PCT Filed Jul. 11, 2019, PCT No. PCT/JP2019/027588
§ 371(c)(1), (2) Date Dec. 9, 2020,
PCT Pub. No. WO2020/017436, PCT Pub. Date Jan. 23, 2020.
Claims priority of application No. 2018-135912 (JP), filed on Jul. 19, 2018.
Prior Publication US 2021/0244925 A1, Aug. 12, 2021
Int. Cl. A61M 37/00 (2006.01)
CPC A61M 37/0015 (2013.01) [A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method of producing a microneedle sheet having at least one microneedle, the method comprising:
preparing a sheet having a first surface and a second surface;
making a first cut in a range from the first surface to the second surface of the sheet to form a first outer edge of a tip end of the microneedle; and
making, after forming the first outer edge, a second cut in a range from the first surface to the second surface of the sheet to form a second outer edge of the tip end of the microneedle, thereby forming the tip end of the microneedle;
wherein the first outer edge is an outer edge extending from an apex of the microneedle to a base of the microneedle, and
wherein the second outer edge is an outer edge positioned on an opposite side to the first outer edge with the apex interposed and extending from the apex toward the base.