US 12,290,640 B2
Noninvasive, regional brain thermal stimulation for inducing relaxation
Eric A. Nofzinger, Allison Park, PA (US); and Jeffrey J. Schirm, Monroeville, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Oct. 22, 2019, as Appl. No. 16/660,691.
Application 16/660,691 is a continuation in part of application No. 16/386,145, filed on Apr. 16, 2019, granted, now 10,610,661.
Application 16/386,145 is a continuation in part of application No. 15/921,528, filed on Mar. 14, 2018, abandoned.
Application 16/386,145 is a continuation in part of application No. 15/597,057, filed on May 16, 2017, abandoned.
Application 15/921,528 is a continuation in part of application No. 14/749,590, filed on Jun. 24, 2015, granted, now 9,669,185.
Application 15/921,528 is a continuation in part of application No. 14/435,515, abandoned, previously published as PCT/US2013/070251, filed on Nov. 15, 2013.
Application 14/749,590 is a continuation of application No. 13/868,015, filed on Apr. 22, 2013, granted, now 9,089,400.
Application 13/868,015 is a continuation of application No. 13/019,477, filed on Feb. 2, 2011, granted, now 8,425,583.
Application 13/019,477 is a continuation in part of application No. 12/288,417, filed on Oct. 20, 2008, granted, now 9,492,313.
Application 13/019,477 is a continuation in part of application No. 11/788,694, filed on Apr. 20, 2007, granted, now 8,236,038.
Claims priority of provisional application 61/859,161, filed on Jul. 26, 2013.
Claims priority of provisional application 61/727,054, filed on Nov. 15, 2012.
Claims priority of provisional application 61/300,768, filed on Feb. 2, 2010.
Claims priority of provisional application 60/793,680, filed on Apr. 20, 2006.
Prior Publication US 2020/0046936 A1, Feb. 13, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 21/02 (2006.01); A61B 17/00 (2006.01); A61F 7/00 (2006.01); A61F 7/02 (2006.01); A61F 7/10 (2006.01); A61H 9/00 (2006.01); A61M 19/00 (2006.01); A61M 21/00 (2006.01); A61N 1/04 (2006.01); A61N 5/06 (2006.01)
CPC A61M 21/02 (2013.01) [A61F 7/0085 (2013.01); A61F 7/10 (2013.01); A61H 9/0007 (2013.01); A61H 9/0078 (2013.01); A61M 19/00 (2013.01); A61M 21/00 (2013.01); A61B 2017/00132 (2013.01); A61F 2007/0002 (2013.01); A61F 2007/0007 (2013.01); A61F 2007/0054 (2013.01); A61F 2007/0056 (2013.01); A61F 7/007 (2013.01); A61F 2007/0075 (2013.01); A61F 2007/0093 (2013.01); A61F 2007/0095 (2013.01); A61F 2007/0096 (2013.01); A61F 2007/0226 (2013.01); A61H 2201/0103 (2013.01); A61H 2201/0161 (2013.01); A61H 2201/0188 (2013.01); A61H 2201/0192 (2013.01); A61H 2201/0207 (2013.01); A61H 2201/0214 (2013.01); A61H 2201/0242 (2013.01); A61H 2201/025 (2013.01); A61H 2201/0257 (2013.01); A61H 2201/10 (2013.01); A61H 2201/102 (2013.01); A61H 2201/1604 (2013.01); A61H 2201/165 (2013.01); A61H 2201/1654 (2013.01); A61H 2201/5035 (2013.01); A61H 2201/5048 (2013.01); A61H 2201/5058 (2013.01); A61H 2201/5082 (2013.01); A61H 2201/5084 (2013.01); A61H 2201/5092 (2013.01); A61H 2205/024 (2013.01); A61H 2205/025 (2013.01); A61H 2230/04 (2013.01); A61H 2230/06 (2013.01); A61H 2230/10 (2013.01); A61H 2230/207 (2013.01); A61H 2230/60 (2013.01); A61M 2021/0066 (2013.01); A61M 2021/0083 (2013.01); A61M 2205/3606 (2013.01); A61M 2205/3626 (2013.01); A61M 2205/3673 (2013.01); A61M 2209/088 (2013.01); A61M 2210/06 (2013.01); A61M 2210/0693 (2013.01); A61N 1/0456 (2013.01); A61N 5/0618 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method of reducing anxiety in an awake subject, the method comprising: positioning an applicator comprising a thermal transfer region in communication with the subject's skin on the subject's forehead; and applying noninvasive, regional brain cooling to the subject's forehead.