US 12,290,633 B2
Systems and methods for adaptive cough detection and adaptive mechanical insufflation-exsufflation (MI-E) therapy
David Aaron Troxell, San Luis Obispo, CA (US); Seunghyun Lee, Valrico, FL (US); and Jon Nilsestuen, Friendswood, TX (US)
Assigned to Koninklijke Philips N.V., Eindhoven (NL)
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed on Aug. 11, 2021, as Appl. No. 17/399,249.
Claims priority of provisional application 63/066,572, filed on Aug. 17, 2020.
Prior Publication US 2022/0047830 A1, Feb. 17, 2022
Int. Cl. A61M 16/00 (2006.01); G05B 19/042 (2006.01); G16H 40/63 (2018.01)
CPC A61M 16/024 (2017.08) [A61M 16/0006 (2014.02); A61M 16/0069 (2014.02); G05B 19/042 (2013.01); G16H 40/63 (2018.01); A61M 2016/0027 (2013.01); A61M 2205/3341 (2013.01); A61M 2230/40 (2013.01); G05B 2219/25255 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A mechanical ventilation system, comprising:
a mechanical ventilator configured to deliver ventilation to a patient; and
an electronic controller programmed to control the mechanical ventilator to perform a mechanical insufflation-exsufflation (MI-E) therapy method including performing a MI-E cycle including:
(i) during an insufflation cycle, delivering pressure to the patient at a positive insufflation gauge pressure;
(ii) during an exsufflation cycle following step (i), delivering pressure to the patient at a negative exsufflation gauge pressure;
(iii) determining, based on a presence or absence of a counter pressure spike during the exsufflation cycle, if a zero-flow point during the exsufflation cycle is caused by an active cough or an upper airway collapse; and
(iv) reducing a magnitude of negative exsufflation gauge pressure for a subsequent exsufflation cycle if it is determined in step (iii) that the zero-flow point is caused by an upper airway collapse.