	US 12,290,616 B2
	Multi-layered polymer film for sustained release of agents
Honglei Wang, Singapore (SG); and Jingnan Luo, Singapore (SG)
Assigned to Foundry Therapeutics, Inc., Menlo Park, CA (US)
Filed by Foundry Therapeutics, Inc., Menlo Park, CA (US)
Filed on Mar. 19, 2024, as Appl. No. 18/609,954.
Application 18/609,954 is a continuation of application No. 17/305,851, filed on Jul. 15, 2021, granted, now 11,964,076.
Application 17/305,851 is a continuation of application No. 16/366,323, filed on Mar. 27, 2019, abandoned.
Application 16/366,323 is a continuation of application No. 15/563,527, abandoned, previously published as PCT/SG2016/050158, filed on Mar. 31, 2016.
Claims priority of application No. 1505527 (GB), filed on Mar. 31, 2015.
Prior Publication US 2024/0226394 A1, Jul. 11, 2024
Int. Cl. A61L 31/16 (2006.01); A61K 31/496 (2006.01); A61K 31/65 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61L 31/04 (2006.01); A61L 31/06 (2006.01); A61L 31/14 (2006.01); A61N 1/375 (2006.01); A61P 31/00 (2006.01)

CPC A61L 31/16 (2013.01) [A61K 31/496 (2013.01); A61K 31/65 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 31/041 (2013.01); A61L 31/06 (2013.01); A61L 31/148 (2013.01); A61N 1/375 (2013.01); A61P 31/00 (2018.01); A61L 2300/404 (2013.01); A61L 2300/406 (2013.01); A61L 2300/602 (2013.01)]

20 Claims

1. A method for manufacturing an implant including an upper layer, an intermediate layer, and a lower layer separate from the upper layer, the method comprising:

forming the intermediate layer by:

preparing a mixture comprising poly (lactide-co-glycolide) (PLGA), an active agent, and a solvent, and

evaporating at least some of the solvent from the mixture to form the intermediate layer, wherein the active agent constitutes from 40 wt % to 80 wt % of the intermediate layer; and

dip coating PLGA onto an upper surface and a lower surface of the intermediate layer to form the upper layer and the lower layer, wherein the upper layer and the lower layer are configured to control release of the active agent from the intermediate layer.