US 12,290,615 B2
Drug coated balloon and preparation method thereof
Liwei Wang, Guangdong (CN); Junyi Huang, Guangdong (CN); Zhijun Zhang, Guangdong (CN); and Bin Li, Guangdong (CN)
Assigned to BROSMED MEDICAL CO., LTD., Dongguan (CN)
Filed by BROSMED MEDICAL CO., LTD., Guangdong (CN)
Filed on Jan. 16, 2024, as Appl. No. 18/414,450.
Application 18/414,450 is a continuation in part of application No. PCT/CN2023/082108, filed on Mar. 17, 2023.
Claims priority of application No. 202211169429.4 (CN), filed on Sep. 22, 2022.
Prior Publication US 2024/0148943 A1, May 9, 2024
Int. Cl. A61L 29/16 (2006.01); A61L 29/04 (2006.01); A61L 29/08 (2006.01)
CPC A61L 29/16 (2013.01) [A61L 29/049 (2013.01); A61L 29/085 (2013.01); A61L 2300/216 (2013.01); A61L 2300/416 (2013.01); A61L 2300/602 (2013.01); A61L 2300/608 (2013.01); A61L 2300/62 (2013.01); A61L 2420/02 (2013.01); A61L 2420/06 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A drug coated balloon, comprising a balloon body and a drug loaded coating layer coated on an outer surface of the balloon body,
wherein the drug loaded coating layer comprises:
a first drug loaded coating component comprising at least two controllable sustained release drugs with different drug release kinetics; and
a second drug loaded coating component comprising an active drug in a free unbound form, dispersed among different controllable sustained release drugs in the first drug loaded coating component and coupling the controllable sustained release drugs onto the balloon body,
wherein both the first drug loaded coating component and the second drug loaded coating component are non-hydrophilic compositions,
wherein the active drug in a free unbound form directly couples the controllable sustained release drugs onto the balloon body, without any additional binding matrix, and
wherein the active drug in a free unbound form is attached to the balloon body in a form of separated drug particles, rather than in a form of drug membranes.