	US 12,290,613 B2
	Micronized compositions composed of bone grafts and methods of making and using the same
John Daniel, Kennesaw, GA (US); Randall Spencer, Kennesaw, GA (US); and Robert Tofe, Kennesaw, GA (US)
Assigned to MiMedx Group, Inc., Marietta, GA (US)
Filed by MiMedx Group, Inc., Marietta, GA (US)
Filed on Oct. 8, 2012, as Appl. No. 13/647,308.
Claims priority of provisional application 61/543,934, filed on Oct. 6, 2011.
Prior Publication US 2014/0017280 A1, Jan. 16, 2014
Int. Cl. A61L 27/36 (2006.01)

CPC A61L 27/3604 (2013.01) [A61L 27/3608 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01); A61L 2430/24 (2013.01)]

15 Claims

1. A micronized placental composition comprising (a) dehydrated micronized particles, selected from the group consisting of micronized placental amnion particles and micronized particles comprising placental amnion and chorion, and (b) one or more bone grafts;

wherein said dehydrated micronized particles comprise a fibroblast cell layer;

wherein the one or more bone grafts are independently selected from the group consisting of an autograft, an allograft, a xenograft, and an alloplast, and any combination thereof;

wherein the amount of said micronized particles to said one or more bone grafts is from 1:99 to 99:1 by volume.