US 12,290,612 B2
Aligned fiber and method of use thereof
Michael Francis, Virginia Beach, VA (US); and Roy Ogle, Virginia Beach, VA (US)
Assigned to LifeNet Health, Virginia Beach, VA (US)
Filed by LifeNet Health, Virginia Beach, VA (US)
Filed on Aug. 10, 2020, as Appl. No. 16/989,307.
Application 16/045,159 is a division of application No. 14/776,106, granted, now 10,137,223, issued on Nov. 27, 2018, previously published as PCT/US2014/025636, filed on Mar. 13, 2014.
Application 16/989,307 is a continuation of application No. 16/045,159, filed on Jul. 25, 2018, granted, now 11,318,227.
Claims priority of provisional application 61/785,031, filed on Mar. 14, 2013.
Prior Publication US 2020/0368386 A1, Nov. 26, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 2/08 (2006.01); A61K 35/32 (2015.01); A61L 27/18 (2006.01); A61L 27/24 (2006.01); A61L 27/26 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/56 (2006.01); C12N 5/071 (2010.01); C12N 5/079 (2010.01); D01D 5/00 (2006.01)
CPC A61L 27/18 (2013.01) [A61L 27/24 (2013.01); A61L 27/26 (2013.01); A61L 27/3604 (2013.01); A61L 27/3633 (2013.01); A61L 27/38 (2013.01); A61L 27/383 (2013.01); A61L 27/56 (2013.01); C12N 5/0618 (2013.01); D01D 5/0076 (2013.01); D01D 5/0092 (2013.01); A61F 2/08 (2013.01); A61F 2240/001 (2013.01); A61L 2400/12 (2013.01); C12N 2533/30 (2013.01); C12N 2533/54 (2013.01); C12N 2533/90 (2013.01)] 25 Claims
 
1. A composite scaffold comprising:
multiple layers of sheets including at least a first layer and a second layer, wherein
the first layer comprises electrospun fibers comprising collagen and a copolymer, wherein a result of a fast Fourier transform (FFT) analysis demonstrates that the first layer fibers are aligned having major adjacent peaks that are about 180° apart from each other, and
the second layer comprises random fibers.