	US 12,290,603 B2
	Tabletization of peptide self-assemblies and methods of making and using the same
Joel Collier, Durham, NC (US); and Sean Kelly, Durham, NC (US)
Assigned to Duke University, Durham, NC (US)
Appl. No. 17/764,406
Filed by Duke University, Durham, NC (US)
PCT Filed Sep. 28, 2020, PCT No. PCT/US2020/053095 § 371(c)(1), (2) Date Mar. 28, 2022, PCT Pub. No. WO2021/062374, PCT Pub. Date Apr. 1, 2021.
Claims priority of provisional application 62/906,893, filed on Sep. 27, 2019.
Prior Publication US 2022/0362159 A1, Nov. 17, 2022
Int. Cl. A61K 9/20 (2006.01); A61K 9/00 (2006.01); A61K 47/60 (2017.01); A61K 47/69 (2017.01)

CPC A61K 9/2095 (2013.01) [A61K 9/0056 (2013.01); A61K 9/2018 (2013.01); A61K 47/60 (2017.08); A61K 47/6929 (2017.08)]

20 Claims

1. A dissolvable tablet formulation comprising

(a) self-assembling peptide-polymer nanofibers comprising a peptide-polymer conjugate comprising

(i) a self-assembling domain comprising a polypeptide and having a C-terminal and N-terminal end;

(ii) a peptide epitope or protein antigen; and

(iii) a mucus-inert domain, wherein (ii) and (iii) are linked opposite ends of the (i) self-assembling domain;

(b) an excipient; and

wherein the dissolvable tablet is suitable for sublingual administration.