US 12,290,540 B2
Strain having ability to lower blood ammonia levels and composition comprising same for neuronal protection
Hyeon Jin Kim, Jeollabuk-do (KR); Sang Woo Kim, Iksan-si (KR); and Seong Tshool Hong, Jeonju-si (KR)
Assigned to JINIS CO., LTD, Jeollabuk-do (KR)
Appl. No. 17/638,528
Filed by JINIS CO., LTD, Jeollabuk-do (KR)
PCT Filed Nov. 19, 2020, PCT No. PCT/KR2020/016352
§ 371(c)(1), (2) Date Mar. 8, 2022,
PCT Pub. No. WO2021/107500, PCT Pub. Date Jun. 3, 2021.
Claims priority of application No. 10-2019-0156386 (KR), filed on Nov. 29, 2019; and application No. 10-2020-0097141 (KR), filed on Aug. 4, 2020.
Prior Publication US 2022/0409678 A1, Dec. 29, 2022
Int. Cl. A61K 39/02 (2006.01); A61K 35/744 (2015.01); A61K 35/747 (2015.01); A61K 39/09 (2006.01); A61P 25/28 (2006.01); C12N 1/00 (2006.01); C12N 1/20 (2006.01)
CPC A61K 35/747 (2013.01) [A61K 35/744 (2013.01); A61P 25/28 (2018.01)] 3 Claims
 
1. Lactobacillus sp. and Streptococcus sp. pair having neuroprotective efficacy by lowering blood ammonia levels in mammals, and said Lactobacillus sp. and Streptococcus sp. pair being selected from the groups that include JBD301+JBD421, JBD301+JBD422, JBD301+JBD423, JBD400+JBD420, JBD401+JBD421, JBD401+JBD422, JBD401+JBD424, JBD402+JBD421, JBD406+JBD420, JBD410+JBD421, JBD410+JBD422, JBD410+JBD427, JBD411+JBD421, JBD411+JBD422, JBD411+JBD424, or JBD411+JBD426, wherein:
JBD301 is Lactobacillus reuteri JBD301 (KCTC 12606BP),
JBD400 is Lactobacillus reuteri JBD400 (KACC 81122BP),
JBD401 is Lactobacillus amylovorus JBD401 (KACC 81052BP),
JBD402 is Lactobacillus plantarum JBD402 (KACC 81121BP),
JBD406 is Lactobacillus rhamnosus JBD406 (KACC 81123BP),
JBD410 is Lactobacillus acidophilus JBD410 (KCTC 11515BP),
JBD411 is Lactobacillus coryniformis JBD411 (KACC 81053BP)
JBD420 is Streptococcus lubneri JBD420 (KACC 81124BP),
JBD421 is Streptococcus lutetiensis JBD421 (KACC 81054BP),
JBD422 is Streptococcus australis JBD422 (KACC 81055BP),
JBD423 is Streptococcus mutans JBD423 (KACC 81056BP),
JBD424 is Streptococcus vestibularis JBD424 (KACC 81057BP),
JBD426 is Streptococcus parasanguinis JBD426 (KACC 81059BP), and
JBD427 is Streptococcus gallinaceus JBD427 (KACC 81060BP).