	US 12,290,539 B2
	Purified anthelmintic compositions and related methods
Raffi Van Aroian, Worcester, MA (US); and Gary R. Ostroff, Worcester, MA (US)
Assigned to UNIVERSITY OF MASSACHUSETTS, Westborough, MA (US)
Filed by UNIVERSITY OF MASSACHUSETTS, Boston, MA (US)
Filed on Oct. 12, 2023, as Appl. No. 18/485,796.
Application 18/485,796 is a division of application No. 16/607,677, granted, now 11,844,815, previously published as PCT/US2018/033962, filed on May 22, 2018.
Claims priority of provisional application 62/510,081, filed on May 23, 2017.
Prior Publication US 2024/0148800 A1, May 9, 2024
Int. Cl. A61K 35/741 (2015.01); A61K 9/48 (2006.01); A61K 38/16 (2006.01); A61P 33/10 (2006.01); A61K 45/06 (2006.01)

CPC A61K 35/741 (2013.01) [A61K 9/48 (2013.01); A61K 38/164 (2013.01); A61P 33/10 (2018.01); A61K 45/06 (2013.01)]

33 Claims

1. A method of treating a parasitic worm or helminth infection in a subject comprising:

administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising isolated native, bioactive nematicidal crystals formed from a single type of nematicidal crystal protein,

wherein the bioactive nematicidal crystals are produced by a non-sporulating form of host bacterium, and

wherein the pharmaceutical composition is substantially free of any bacterial spores or host bacterial proteins other than nematicidal crystal protein in the form of a crystal.