US 12,290,520 B2
Methods of use of emulsion formulations of aprepitant
Thomas B. Ottoboni, Belmont, CA (US); and Han Han, Mountain View, CA (US)
Assigned to Heron Therapeutics, Inc., San Diego, CA (US)
Filed by Heron Therapeutics, Inc., San Diego, CA (US)
Filed on Jan. 9, 2024, as Appl. No. 18/408,463.
Application 18/408,463 is a continuation of application No. 17/194,114, filed on Mar. 5, 2021, abandoned.
Application 17/194,114 is a continuation of application No. 16/669,262, filed on Oct. 30, 2019, granted, now 10,953,018.
Application 16/669,262 is a continuation of application No. 15/398,928, filed on Jan. 5, 2017, granted, now 10,500,208, issued on Dec. 10, 2019.
Application 15/398,928 is a continuation of application No. 15/083,071, filed on Mar. 28, 2016, granted, now 9,561,229, issued on Feb. 7, 2017.
Application 15/083,071 is a continuation of application No. 14/859,013, filed on Sep. 18, 2015, granted, now 9,808,465, issued on Nov. 7, 2017.
Claims priority of provisional application 62/052,948, filed on Sep. 19, 2014.
Prior Publication US 2024/0139201 A1, May 2, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/10 (2006.01); A61K 9/00 (2006.01); A61K 9/107 (2006.01); A61K 31/00 (2006.01); A61K 31/5377 (2006.01); A61K 31/573 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); A61K 47/44 (2017.01)
CPC A61K 31/5377 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/107 (2013.01); A61K 31/573 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/18 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/44 (2013.01)] 24 Claims
OG exemplary drawing
 
1. An injectable emulsion, comprising:
aprepitant;
13 wt/wt % to 20 wt/wt % of an egg lecithin;
9 wt/wt % to 10 wt/wt % of soybean oil;
a co-emulsifier which is an alcohol, wherein the alcohol is present in the emulsion at less than 10 wt/wt %;
a tonicity modifier;
a pH modifier, wherein the pH modifier is sodium oleate; and
water;
wherein the ratio of egg lecithin to aprepitant is between about 20:1 to 25:1;
wherein the pH of the emulsion ranges from about 7.5 to 9.0; and,
wherein the emulsion is physically stable.