CPC A61K 31/517 (2013.01) [A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/26 (2013.01); A61K 47/38 (2013.01); A61K 9/0048 (2013.01)] | 15 Claims |
1. A method of treating ocular surface pain in a subject in need thereof, comprising ocularly administering to the subject a formulation, comprising:
a suspension of 4-(7-Hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)benzonitrile (compound I) or a salt, co-crystal, or polymorph thereof, in an amount of about 0.5% w/v to about 3.5% w/v;
tyloxapol in an amount of about 0.04% w/v to about 0.06% w/V;
carbomer homopolymer Type B in an amount from about 0.05% w/v to about 0.4% w/v;
a tonicity agent;
a buffer;
sodium chloride in an amount of from 0.01% w/v to about 1% w/V;
optionally, a preservative; and
water in quantity sufficient (qs) to 100%.
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