US 12,290,360 B2
Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods
Ning Yang, Los Angeles, CA (US); Raghavendhar Gautham, Northridge, CA (US); and Rajiv Shah, Rancho Palos Verdes, CA (US)
Assigned to Medtronic MiniMed, Inc., Northridge, CA (US)
Filed by Medtronic MiniMed, Inc., Northridge, CA (US)
Filed on Nov. 1, 2021, as Appl. No. 17/515,587.
Application 17/515,587 is a continuation of application No. 16/170,901, filed on Oct. 25, 2018, granted, now 11,160,477, issued on Nov. 2, 2021.
Application 16/170,901 is a continuation of application No. 13/778,630, filed on Feb. 27, 2013, granted, now 10,156,543, issued on Dec. 18, 2018.
Claims priority of provisional application 61/755,811, filed on Jan. 23, 2013.
Claims priority of provisional application 61/754,479, filed on Jan. 18, 2013.
Claims priority of provisional application 61/754,475, filed on Jan. 18, 2013.
Claims priority of provisional application 61/754,483, filed on Jan. 18, 2013.
Claims priority of provisional application 61/754,485, filed on Jan. 18, 2013.
Claims priority of provisional application 61/657,517, filed on Jun. 8, 2012.
Prior Publication US 2022/0047187 A1, Feb. 17, 2022
Int. Cl. A61B 5/1495 (2006.01); A61B 5/00 (2006.01); A61B 5/0537 (2021.01); A61B 5/0538 (2021.01); A61B 5/145 (2006.01); A61B 5/1459 (2006.01); A61B 5/1473 (2006.01); A61B 5/1486 (2006.01); A61M 5/142 (2006.01); A61M 5/158 (2006.01); A61M 5/172 (2006.01); G01N 27/02 (2006.01); G01N 27/416 (2006.01); G01N 33/49 (2006.01); G01N 33/66 (2006.01); G01N 33/96 (2006.01); G01R 35/00 (2006.01); G08B 21/18 (2006.01)
CPC A61B 5/1495 (2013.01) [A61B 5/0537 (2013.01); A61B 5/0538 (2013.01); A61B 5/14503 (2013.01); A61B 5/14532 (2013.01); A61B 5/1459 (2013.01); A61B 5/1473 (2013.01); A61B 5/14865 (2013.01); A61B 5/4839 (2013.01); A61B 5/6849 (2013.01); A61B 5/6852 (2013.01); A61B 5/6886 (2013.01); A61B 5/7203 (2013.01); A61B 5/7221 (2013.01); A61B 5/7225 (2013.01); A61B 5/7242 (2013.01); A61B 5/746 (2013.01); A61M 5/14276 (2013.01); A61M 5/1582 (2013.01); A61M 5/1723 (2013.01); G01N 27/026 (2013.01); G01N 27/028 (2013.01); G01N 27/416 (2013.01); G01N 27/4163 (2013.01); G01N 33/49 (2013.01); G01N 33/66 (2013.01); G01N 33/96 (2013.01); G01R 35/00 (2013.01); G01R 35/005 (2013.01); G08B 21/182 (2013.01); A61B 2562/0214 (2013.01); A61B 2562/04 (2013.01); A61M 5/14244 (2013.01); A61M 2005/1726 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for detection of sensitivity loss for a working electrode of a sensor, the method comprising:
accessing, by a microprocessor, multiple sets of impedance related data for the working electrode over time, wherein an electrochemical impedance spectroscopy (EIS) procedure is performed to generate the multiple sets of impedance related data, and each of the multiple sets of impedance related data includes data for at least one impedance-related parameter that is substantially glucose-independent;
based on multiple sets of impedance related data, calculating, by the microprocessor, real impedance values at 0.105 Hz and voltages at the working electrode;
determining, by the microprocessor, based on the real impedance values and voltages over time, that the working electrode is experiencing an oxygen deficiency-led loss of sensitivity based on the real impedance values becoming more positive over time and the voltages reaching a rail voltage; and
based on the determination that the working electrode is experiencing an oxygen deficiency-led loss of sensitivity, generating, by the microprocessor, an alert for presentation to a user of the sensor, the alert indicating that the sensor should be replaced.