US 12,290,359 B2
Sensor array systems and methods for detecting multiple analytes
Yi Wang, Danville, CA (US); Hyun Cho, Berkeley, CA (US); Benjamin J. Feldman, Berkeley, CA (US); Kuan-Chou Chen, Fremont, CA (US); Lam N. Tran, Danville, CA (US); Stephen Oja, Reno, NV (US); and Tianmei Ouyang, Saratoga, CA (US)
Assigned to ABBOTT DIABETES CARE INC., Alameda, CA (US)
Filed by ABBOTT DIABETES CARE INC., Alameda, CA (US)
Filed on Dec. 30, 2020, as Appl. No. 17/138,477.
Claims priority of provisional application 62/956,943, filed on Jan. 3, 2020.
Prior Publication US 2021/0219885 A1, Jul. 22, 2021
Int. Cl. A61B 5/1486 (2006.01); A61B 5/145 (2006.01)
CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01); A61B 2562/125 (2013.01); A61B 2562/16 (2013.01)] 11 Claims
OG exemplary drawing
 
1. An electrochemical analyte sensor for continuously detecting glucose and ketones in vivo, the sensor comprising:
a substrate;
a first working electrode disposed on the substrate;
a dielectric layer disposed on the first working electrode;
a second working electrode disposed on the dielectric layer;
a ketones-responsive active area disposed upon a surface of the first working electrode;
a glucose-responsive active area disposed upon a surface of the second working electrode;
a first membrane that is permeable to ketones and overcoats the ketones-responsive active area; and
a second membrane that is permeable to glucose and overcoats the ketones-responsive and the glucose-responsive active areas,
wherein the ketones-responsive active area is located closer to a distal end of the sensor than the glucose-responsive active area, and wherein a distance between the ketones-responsive active area and the glucose-responsive active area is 0.4 mm to 1.1 mm, and
wherein the sensor is partially insertable into skin such that the distal end of the sensor is in contact with an interstitial fluid to continuously detect glucose and ketones in vivo.