US 12,290,355 B2
Continuous potassium sensors and methods of use thereof
Zenghe Liu, Alameda, CA (US); Barry S. Kreutz, Chicago, IL (US); Yagya Raj Ojha, Alameda, CA (US); Benjamin J. Feldman, Berkeley, CA (US); Thomas P Leary, Peoria, AZ (US); and Tram Nguyen, Suisun, CA (US)
Assigned to ABBOTT DIABETES CARE INC., Almeda, CA (US)
Filed by Abbott Diabetes Care Inc., Alameda, CA (US)
Filed on Dec. 23, 2021, as Appl. No. 17/561,383.
Claims priority of provisional application 63/257,484, filed on Oct. 19, 2021.
Claims priority of provisional application 63/132,669, filed on Dec. 31, 2020.
Claims priority of provisional application 63/129,793, filed on Dec. 23, 2020.
Prior Publication US 2022/0192548 A1, Jun. 23, 2022
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/1486 (2006.01)
CPC A61B 5/14546 (2013.01) [A61B 5/14865 (2013.01); A61B 5/7246 (2013.01); A61B 5/0004 (2013.01); A61B 5/6849 (2013.01); A61B 2562/04 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An analyte sensor for detecting potassium comprising:
(i) a sensor tail comprising at least a first working electrode and a second working electrode;
(ii) a first analyte-responsive active area disposed upon a surface of the first working electrode, wherein the first analyte-responsive active area comprises a first aspartate oxidase and a first asparaginase;
(iii) a second analyte-responsive active area disposed upon a surface of the second working electrode, wherein the second analyte-responsive active area comprises a second aspartate oxidase and a second asparaginase;
wherein the first aspartate oxidase and the second aspartate oxidase have different potassium dependencies and wherein the first asparaginase and the second asparaginase have different potassium dependencies;
and
(iv) a first mass transport limiting membrane permeable to potassium that overcoats the first analyte-responsive active area, the second analyte-responsive area, or both the first and second analyte-responsive active areas.