| CPC A61B 5/14532 (2013.01) [A61B 5/01 (2013.01); A61B 5/14503 (2013.01); A61B 5/7225 (2013.01); A61B 5/1473 (2013.01); A61B 2560/0252 (2013.01); A61B 2562/0271 (2013.01)] | 12 Claims |

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7. A glucose monitoring system, comprising:
a glucose monitoring device, comprising:
a first processor and a first memory communicably coupled to the first processor;
an in vivo glucose sensor comprising a sensing area communicably coupled to the first processor, wherein the in vivo glucose sensor comprises a first portion configured to be arranged above a skin surface of a user and a second portion configured to be positioned below the skin surface and in contact with interstitial fluid, wherein the second portion comprises the sensing area; and
a temperature sensor communicably coupled to the first processor, wherein the temperature sensor is disposed in a housing and is configured to be arranged above the skin surface of the user; and
a receiver configured to communicate with the glucose monitoring device, the receiver comprising:
a second processor and a second memory communicably coupled to the second processor;
wherein at least one of the first memory and the second memory includes instructions stored therein that, when executed by at least one of the first and second processors, cause the at least one of the first and second processors to:
receive a sensor signal from the in vivo glucose sensor;
detect a temperature measurement from the temperature sensor;
determine an ambient-compensated temperature from the temperature measurement using an offset term based on a core body temperature, wherein the ambient-compensated temperature is an estimated temperature of the sensing area; and
determine a temperature-compensated glucose sensor signal with the thus determined ambient-compensated temperature.
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