US 12,290,353 B2
Thread-based real-time monitoring of bodily fluids
Sameer Sonkusale, Lincoln, MA (US); and Trupti Terse, Natick, MA (US)
Assigned to Trustees of Tufts College, Medford, MA (US)
Appl. No. 17/276,970
Filed by Trustees of Tufts College, Medford, MA (US)
PCT Filed Sep. 18, 2019, PCT No. PCT/US2019/051636
§ 371(c)(1), (2) Date Mar. 17, 2021,
PCT Pub. No. WO2020/106353, PCT Pub. Date May 28, 2020.
Claims priority of provisional application 62/732,627, filed on Sep. 18, 2018.
Prior Publication US 2022/0031204 A1, Feb. 3, 2022
Int. Cl. B01L 3/00 (2006.01); A47L 15/42 (2006.01); A61B 5/145 (2006.01); A61B 5/1477 (2006.01); A61L 27/16 (2006.01); A61L 27/56 (2006.01); B01F 23/00 (2022.01); B01F 23/41 (2022.01); B01F 101/23 (2022.01); B01L 7/00 (2006.01); B01L 9/00 (2006.01); B23Q 17/24 (2006.01); C07K 14/705 (2006.01); C08F 220/56 (2006.01); C08L 33/26 (2006.01); C12M 1/34 (2006.01); C12Q 1/04 (2006.01); C12Q 1/18 (2006.01); C12Q 1/6844 (2018.01); C12Q 1/686 (2018.01); G01N 1/31 (2006.01); G01N 21/17 (2006.01); G01N 21/3577 (2014.01); G01N 21/359 (2014.01); G01N 21/39 (2006.01); G01N 21/45 (2006.01); G01N 21/64 (2006.01); G01N 21/77 (2006.01); G01N 21/78 (2006.01); G01N 27/414 (2006.01); G01N 30/12 (2006.01); G01N 30/68 (2006.01); G01N 30/70 (2006.01); G01N 30/72 (2006.01); G01N 30/88 (2006.01); G01N 33/00 (2006.01); G01N 33/18 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01); G01N 33/74 (2006.01); G01N 35/00 (2006.01); G01N 35/04 (2006.01); G01N 35/10 (2006.01); G06F 1/16 (2006.01); G06T 7/00 (2017.01); G06T 7/90 (2017.01); G16H 20/60 (2018.01); G16H 40/63 (2018.01); H10K 10/46 (2023.01); H10K 85/00 (2023.01); H10K 85/20 (2023.01)
CPC A61B 5/14517 (2013.01) [A61B 5/1477 (2013.01); G06F 1/163 (2013.01)] 23 Claims
OG exemplary drawing
 
1. An apparatus comprising a wearable sensor configured for real-time multiplexed monitoring of biomarkers in an external bodily fluid, said wearable sensor comprising a substrate, a communication interface disposed on said substrate, a wick disposed on said substrate, and a thread disposed on said wick, said thread being a sensor thread that has a functionalized region, wherein said wick wicks said external bodily fluid to said functionalized region, wherein said communication interface transmits data indicative of what said sensor thread has measured in said external bodily fluid, wherein said thread is one of a plurality of threads, each of which comprises a proximal end that connects to a corresponding wire in a bundle of wires, wherein each of said wires in said bundle of wires connects to said communication interface, and wherein said communication interface communicates data indicative of measurements obtained by each of said threads for storage or real-time data analysis, wherein said thread is disposed on a substrate selected from the group consisting of a bandage and a dermal patch, said substrate having an outer face.