US 11,971,384 B2
Using electrophoresis for disease detection based on controlled molecular charge
Peter Galen, Portland, OR (US); Ariane Elizabeth Erickson, Portland, OR (US); David Richard Bell, Issaquah, WA (US); Matthew Christian Lind, Portland, OR (US); Tyler Witte, Portland, OR (US); and Umut Atakan Gurkan, Shaker Heights, OH (US)
Assigned to Hemex Health, Inc., Portland, OR (US)
Filed by HEMEX HEALTH, INC., Portland, OR (US)
Filed on Oct. 18, 2021, as Appl. No. 17/504,363.
Application 17/504,363 is a continuation of application No. 17/232,130, filed on Apr. 15, 2021, granted, now 11,255,815.
Claims priority of provisional application 63/010,570, filed on Apr. 15, 2020.
Prior Publication US 2022/0042946 A1, Feb. 10, 2022
Int. Cl. G01N 27/447 (2006.01)
CPC G01N 27/44726 (2013.01) 20 Claims
OG exemplary drawing
 
1. A diagnostic system, comprising:
a processing circuitry configured to:
evaluate an image of or a band detection characteristic of an electrophoresis test result having a labeled bound complex that is applied to a substrate, the labeled bound complex including a labeled binder with a binder charge profile that is bound to a compound in a patient sample;
receive a data signal including a migration pattern of the labeled bound complex produced in response to an applied electric potential, the migration pattern generated as the labeled bound complex migrates across the substrate at a migration velocity over a time period to produce the labeled bound complex band on the substrate;
identify presence of the compound based on the labeled bound complex band and one or both of the migration pattern and a feature or characteristic of the migration velocity; and
an output configured to output a data signal that includes the identification of the presence of the compound.