	US 11,970,582 B2
	Thermoresponsive FDM printer filament for forming vascular channels in hydrogels
Leon M. Bellan, Nashville, TN (US); and John Rector, Nashville, TN (US)
Assigned to Vanderbilt University, Nashville, TN (US)
Appl. No. 17/260,979
Filed by Vanderbilt University, Nashville, TN (US)
PCT Filed Aug. 20, 2019, PCT No. PCT/US2019/047352 § 371(c)(1), (2) Date Jan. 15, 2021, PCT Pub. No. WO2020/041376, PCT Pub. Date Feb. 27, 2020.
Claims priority of provisional application 62/719,785, filed on Aug. 20, 2018.
Prior Publication US 2021/0292489 A1, Sep. 23, 2021
Int. Cl. B33Y 10/00 (2015.01); B33Y 70/00 (2020.01); B33Y 80/00 (2015.01); C08F 218/08 (2006.01); C08F 226/06 (2006.01); C08G 65/332 (2006.01); C08G 81/02 (2006.01); C08J 3/075 (2006.01); C12M 1/12 (2006.01); C12N 5/071 (2010.01)

CPC C08G 81/024 (2013.01) [B33Y 10/00 (2014.12); B33Y 70/00 (2014.12); B33Y 80/00 (2014.12); C08F 218/08 (2013.01); C08F 226/06 (2013.01); C08G 65/3322 (2013.01); C08J 3/075 (2013.01); C12M 25/14 (2013.01); C12N 5/069 (2013.01); C08G 2210/00 (2013.01); C12N 2513/00 (2013.01); C12N 2533/30 (2013.01); C12N 2533/54 (2013.01)]

8 Claims

1. A method for preparing a solid scaffold, the method comprising: printing a biocompatible polymer composition comprising a thermoresponsive polymer using a fused deposition modelling printer to form the solid scaffold, wherein the biocompatible polymer composition has a disintegration temperature of about 4° C. to about 37° C., wherein the polymer composition is in a solid or gel state above the disintegration temperature, and wherein the polymer composition is in a liquid state below the disintegration temperature.