US 11,969,527 B2
Drug-eluting biomaterials and related methods
Khatija Pinky Ali, Brooklyn, NY (US)
Assigned to BioSapien Inc., New York, NY (US)
Filed by BioSapien Inc., New York, NY (US)
Filed on Jan. 15, 2021, as Appl. No. 17/150,239.
Application 17/150,239 is a continuation of application No. 16/723,697, filed on Dec. 20, 2019, granted, now 10,926,005.
Claims priority of provisional application 62/783,430, filed on Dec. 21, 2018.
Prior Publication US 2021/0379251 A1, Dec. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/14 (2006.01); A61K 31/513 (2006.01); A61K 31/7068 (2006.01); A61L 31/02 (2006.01); A61L 31/04 (2006.01); A61L 31/06 (2006.01); A61L 31/16 (2006.01)
CPC A61L 31/146 (2013.01) [A61K 31/513 (2013.01); A61K 31/7068 (2013.01); A61L 31/026 (2013.01); A61L 31/048 (2013.01); A61L 31/06 (2013.01); A61L 31/16 (2013.01); A61L 2300/216 (2013.01); A61L 2300/232 (2013.01); A61L 2300/402 (2013.01); A61L 2300/41 (2013.01); A61L 2300/416 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of decreasing growth rate of a tumor having colorectal cancer cells in a subject, the method comprising implanting a biomaterial to a target site in the subject, wherein the target site comprises the tumor, wherein the tumor comprises the colorectal cancer cells, wherein the biomaterial comprises a first plurality of geometric elements and a therapeutically-effective amount of a therapeutic agent, wherein the therapeutic agent is 5-fluorouracil,
wherein, upon the implanting, the therapeutically-effective amount of the therapeutic agent is released from the biomaterial at the target site, to effect a decrease in the growth rate of the tumor; and
wherein:
a first geometric element of the first plurality of geometric elements is formed by a first porous border, wherein the first porous border comprises a polymer and the therapeutic agent;
a second geometric element of the first plurality of geometric elements is formed by a non-porous border and a first solid region comprising the polymer, wherein the therapeutic agent cannot diffuse into the second geometric element from the first porous border;
the first solid region is adjacent to and within the non-porous border; and
a portion of the first porous border is adjacent to a portion of the non-porous border.