US 11,968,974 B2
Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs
Matthew Bacchetta, Tenafly, NJ (US); Scott Chicotka, New York, NY (US); Kenmond Fung, New York, NY (US); Brandon Guenthart, New York, NY (US); John O'Neill, New York, NY (US); and Gordana Vunjak-Novakovic, New York, NY (US)
Assigned to The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed on Jan. 10, 2019, as Appl. No. 16/244,283.
Application 16/244,283 is a continuation of application No. PCT/US2017/041990, filed on Jul. 13, 2017.
Claims priority of provisional application 62/472,744, filed on Mar. 17, 2017.
Claims priority of provisional application 62/361,843, filed on Jul. 13, 2016.
Prior Publication US 2019/0141985 A1, May 16, 2019
Int. Cl. C12M 3/00 (2006.01); A01N 1/00 (2006.01); A01N 1/02 (2006.01); A61J 1/00 (2023.01); A61M 1/16 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); A61M 1/36 (2006.01); A61M 1/38 (2006.01)
CPC A01N 1/021 (2013.01) [A01N 1/02 (2013.01); A01N 1/0247 (2013.01); A61J 1/00 (2013.01); A61M 1/16 (2013.01); C12M 29/12 (2013.01); C12M 29/14 (2013.01); C12M 41/16 (2013.01); A01N 1/0278 (2013.01); A61M 1/3621 (2013.01); A61M 1/38 (2013.01); A61M 2210/1039 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A system for maintaining an extracorporeal organ, tissue or bioengineered graft, comprising
an extracorporeal chamber to contain and support the organ, tissue or bioengineered graft; wherein the chamber comprises a time- and temperature-controlled humidifier and misting spray onto the organ, tissue or bioengineered graft and into the chamber to maintain a humid environment within the chamber; and
an extracorporeal cross-circulation circuit to connect the organ, tissue or bioengineered graft with a host organism for cross-circulation of blood or plasma, comprising
fluid conduits providing flow of the blood or plasma between a vascular system of the host organism to vasculature of the organ, tissue or bioengineered graft
an arterial pressure sensor for sensing extracorporeal in-flow line pressure;
a venous pressure sensor for sensing extracorporeal out-flow line pressure; and
a controller configured to control a circulating pump to regulate blood or plasma flow within a range of 5% to 10% of cardiac output of the host organism based on the trans-organ pressure difference between arterial and venous pressure measured by the arterial pressure sensor and the venous pressure sensor.