US 12,288,323 B2
Mapping image signatures of cancer cells to genetic signatures
Shrutin Ulmann, Bangalore (IN); and Prasad Raghotham Venkat, Bangalore (IN)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 17/285,745
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Oct. 15, 2019, PCT No. PCT/EP2019/077915
§ 371(c)(1), (2) Date Apr. 15, 2021,
PCT Pub. No. WO2020/078974, PCT Pub. Date Apr. 23, 2020.
Claims priority of provisional application 62/746,612, filed on Oct. 17, 2018.
Prior Publication US 2022/0004737 A1, Jan. 6, 2022
Int. Cl. G06T 7/00 (2017.01); G06V 10/764 (2022.01); G06V 20/69 (2022.01); G16H 10/40 (2018.01); G16H 15/00 (2018.01); G16H 20/00 (2018.01); G16H 30/40 (2018.01); G16H 50/20 (2018.01)
CPC G06T 7/0012 (2013.01) [G06T 7/0014 (2013.01); G06V 10/764 (2022.01); G06V 20/698 (2022.01); G16H 10/40 (2018.01); G16H 15/00 (2018.01); G16H 20/00 (2018.01); G16H 30/40 (2018.01); G16H 50/20 (2018.01); G06T 2207/20081 (2013.01); G06T 2207/30024 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A computer-implemented method for identifying a course of treatment specific to an identified cancer cell type in a sample from an individual, the method comprising:
obtaining, using a CCD or CMOS imaging device, one or more images of one or more cancer cells in the sample from the individual;
obtaining, using an audiometric imaging device, information of a second mode about the cancer cells;
processing, using an imaging processor, both the one or more obtained images and the obtained information of a second mode about the one or more cancer cells to extract one or more image coefficients, wherein the one or more image coefficients comprises an identification of one or more image features, the image features comprising one or more cellular characteristics of the one or more cancer cells in the sample;
mapping, using a trained classifier, the one or more image coefficients to a cancer cell type and a genetic signature associated with said cancer cell type;
identifying, based on mapping the one or more image coefficients to a cancer cell type and associated genetic signature, one or more cancer cell types and associated genetic signatures in the sample; and
identifying, based on the identified one or more cancer cell types and associated genetic signatures in the sample, a course of treatment specific to the one or more cancer cell types and genetic signatures.