US 12,287,490 B2
Apparatus and methods for controlling heating of an objective in a linescanning sequencing system to improve resolution
Danilo Condello, New York, NY (US); Dakota Watson, San Diego, CA (US); Andrew Carson, Carlsbad, CA (US); Vincent Hsieh, San Diego, CA (US); Steven Boege, San Mateo, CA (US); Changqin Ding, Foster City, CA (US); and Stanley Hong, Menlo Park, CA (US)
Assigned to Illumina, Inc., San Diego, CA (US)
Filed by ILLUMINA, INC., San Diego, CA (US)
Filed on Nov. 4, 2022, as Appl. No. 17/981,206.
Claims priority of provisional application 63/282,555, filed on Nov. 23, 2021.
Claims priority of provisional application 63/277,992, filed on Nov. 10, 2021.
Prior Publication US 2023/0143682 A1, May 11, 2023
Int. Cl. G02B 27/09 (2006.01); G01N 21/64 (2006.01); G02B 26/10 (2006.01)
CPC G02B 27/0927 (2013.01) [G01N 21/6428 (2013.01); G01N 21/6456 (2013.01); G02B 26/101 (2013.01); G02B 27/0916 (2013.01); G02B 27/0955 (2013.01); G02B 27/0994 (2013.01); G01N 2021/6439 (2013.01)] 26 Claims
OG exemplary drawing
 
1. An apparatus, comprising:
a beam source for providing input radiation;
a beam shaping group comprising one or more optical elements positioned to receive the input radiation from the beam source and to generate a beam having a long axis, and a short axis perpendicular to the long axis, and wherein the one or more optical elements comprises a modifier configured to perform beam shaping on the input radiation to broaden the beam in a direction along the short axis to form a shaped beam;
an objective positioned to receive the shaped beam and to transform the shaped beam into a probe beam, the objective further configured to provide the probe beam to a focal plane of the objective for optically probing a sample,
wherein the beam shaping group is configured to adjust one or more properties of the shaped beam over time to generally uniformly heat the objective over a region of incidence for the shaped beam.