US 12,287,328 B2
Fully automated chemiluminescence immunoassay analyzer
Huaming Xu, Shenzhen (CN); Yundong Qi, Shenzhen (CN); Wangfu Chen, Shenzhen (CN); Meng Xian, Shenzhen (CN); Gansong Shen, Shenzhen (CN); Zhibin Cheng, Shenzhen (CN); and Jianjun Peng, Shenzhen (CN)
Assigned to CHENGDU SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD., Chengdu (CN); and SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., Shenzhen (CN)
Filed by CHENGDU SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD., Chengdu (CN); and SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., Shenzhen (CN)
Filed on Jul. 24, 2020, as Appl. No. 16/938,888.
Application 16/938,888 is a continuation of application No. PCT/CN2019/074486, filed on Feb. 1, 2019.
Claims priority of application No. 201810130696.8 (CN), filed on Feb. 8, 2018; and application No. 201810253017.6 (CN), filed on Mar. 26, 2018.
Prior Publication US 2020/0355676 A1, Nov. 12, 2020
Int. Cl. G01N 33/53 (2006.01); C12M 1/12 (2006.01); G01N 35/02 (2006.01); G01N 35/04 (2006.01)
CPC G01N 33/5304 (2013.01) [C12M 37/00 (2013.01); G01N 35/025 (2013.01); G01N 2035/0444 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A fully automated chemiluminescence immunoassay analyzer, comprising:
a sample and reagent receiving device for receiving a sample and a reagent, wherein the sample and reagent receiving device comprises a sample receiving mechanism for receiving the sample and a reagent receiving mechanism for receiving the reagent, the sample receiving mechanism is sleeved outside the reagent receiving mechanism, and the sample receiving mechanism and the reagent receiving mechanism are capable of rotating independently of each other;
a dispensing device for aspirating and discharging the sample and the reagent, wherein the dispensing device is located above the sample and reagent receiving device, and respectively transfers the sample and the reagent into a reaction vessel in a mixing device;
the mixing device for mixing the sample and the reagent in the reaction vessel;
an incubation and luminescence detection device for incubation and luminescence detection;
a magnetic separation cleaning device for separation cleaning an analyte and impurities in the reaction vessel;
a reaction vessel grasping device for transferring the reaction vessel, wherein the reaction vessel grasping device transfers the reaction vessel into the mixing device, transfers the reaction vessel from the mixing device to the incubation and luminescence detection device to perform the incubation, transfers the reaction vessel to the magnetic separation cleaning device to perform the separation cleaning after the incubation, and transfers the reaction vessel into the incubation and luminescence detection device to perform the luminescence detection after the separation cleaning; and
a liquid path device respectively connected to the dispensing device and the magnetic separation cleaning device, wherein the liquid path device is configured to inject or discharge a cleaning liquid into or from the magnetic separation cleaning device,
wherein the incubation and luminescence detection device comprises a sample incubation mechanism and a sample detection mechanism, wherein the sample detection mechanism detects the reaction vessel;
the sample incubation mechanism comprises an incubation block and a heating component configured to heat the incubation block, the incubation block is provided with a plurality of incubation holes arranged in an array, and each of the incubation holes is configured to receive the reaction vessel; and
the sample detection mechanism is disposed on the sample incubation mechanism, and located at a side face of the incubation block,
wherein the incubation block is provided with a luminescence detection hole arranged corresponding to the sample detection mechanism, wherein the luminescence detection hole is within the incubation block, and wherein the luminescence detection hole is configured to accommodate the reaction vessel, the reaction vessel after the incubation is transferred from one of the incubation holes into the luminescence detection hole, and the reaction vessel accommodated in the luminescence detection hole is detected by the sample detection mechanism.