	US 12,287,319 B2
	Methods and systems for determining platelet concentration
Huan Qi, Shenzhen (CN); Bo Ye, Shenzhen (CN); Wenbo Zheng, Shenzhen (CN); Changsong Hu, Shenzhen (CN); and Qi Yu, Shenzhen (CN)
Assigned to SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., Shenzhen (CN)
Filed by SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., Shenzhen (CN)
Filed on Dec. 11, 2023, as Appl. No. 18/536,047.
Application 18/536,047 is a continuation of application No. 17/075,603, filed on Oct. 20, 2020, granted, now 11,841,358.
Application 17/075,603 is a continuation of application No. PCT/CN2019/084687, filed on Apr. 26, 2019.
Claims priority of application No. PCT/CN2018/085197 (WO), filed on Apr. 28, 2018.
Prior Publication US 2024/0133864 A1, Apr. 25, 2024 Prior Publication US 2024/0230621 A9, Jul. 11, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/49 (2006.01); G01N 15/06 (2006.01); G01N 33/487 (2006.01); G16H 10/40 (2018.01); G16H 15/00 (2018.01); G16H 40/67 (2018.01); G01N 15/01 (2024.01); G01N 15/075 (2024.01)

CPC G01N 33/49 (2013.01) [G01N 15/0656 (2013.01); G01N 33/48707 (2013.01); G16H 10/40 (2018.01); G16H 15/00 (2018.01); G16H 40/67 (2018.01); G01N 2015/018 (2024.01); G01N 15/075 (2024.01)]

21 Claims

1. A method for analyzing a blood sample, comprising:

acquiring DC impedance signals of a first suspension from the blood sample;

acquiring at least two types of optical signals of a second suspension from the blood sample, wherein the at least two types of optical signals comprise forward angle light scatter signals and first optical signals for providing cellular content information;

acquiring a first platelet distribution using the DC impedance signals;

acquiring a second platelet distribution using the at least two types of optical signals; and

acquiring a third platelet distribution using the first platelet distribution and the second platelet distribution;

wherein the first suspension is formed by mixing a first aliquot of the blood sample with a diluent, and the second suspension is formed by mixing a second aliquot of the blood sample with a treatment reagent, which comprises a lytic agent to lyse red blood cells in the second aliquot of the blood sample.