US 12,287,291 B1
Method and miniaturized apparatus for Raman spectroscopy using rotatable diffraction grating and slit
Miyeon Jue, Seoul (KR); Young Kyu Kim, Seoul (KR); and Aram Hong, Seoul (KR)
Assigned to Apollon Inc., Cheongju-si (KR)
Filed by Apollon Inc., Cheongju-si (KR)
Filed on Oct. 29, 2024, as Appl. No. 18/930,957.
Claims priority of application No. 10-2023-0176641 (KR), filed on Dec. 7, 2023.
Int. Cl. G01J 3/44 (2006.01); G01N 21/65 (2006.01)
CPC G01N 21/65 (2013.01) [G01N 2201/0221 (2013.01); G01N 2201/025 (2013.01); G01N 2201/126 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A compact Raman spectroscopic analysis device, comprising:
a housing that forms an internal accommodation space therein;
a light source unit that is disposed within the housing and irradiates light onto a subject, wherein the light source unit includes a light source and a reference light source;
a light receiving unit that is disposed within the housing and receives light reflected or scattered from the subject to obtain a Raman spectrum; and
a processor that is disposed in the housing and configured to analyze biological material of the subject based on a peak area value of a Raman spectrum range corresponding to the biological material,
wherein the light receiving unit comprises:
a diffraction grating that reflects the reflected or scattered light;
a slit through which the reflected light passes;
an actuator for adjusting a width of the slit; and
a light detector,
wherein the diffraction grating is rotated by a driving unit to allow an amount of light and a wavelength band that reaches the light detector to be adjusted,
wherein a reference position for rotational operation of the diffraction grating is established using the reference light source such that the reference position is set to a corresponding rotational position of the diffraction grating based on a signal of the reference light source incident on the diffraction grating,
wherein the processor is configured to cause the actuator to adjust the width of the slit,
wherein, prior to acquiring a Raman signal using the light source, the processor is configured to set a position of the diffraction grating and the width the slit using the reference light source, and
wherein the processor is configured to:
cause the actuator to set the width of the slit to a first width to acquire a Raman signal spectrum; and
acquire the Raman signal spectrum of the biological material while decreasing the width of the slit so as to acquire the Raman signal with a plurality of wavelength resolutions.