US 12,287,289 B2
Raman analysis of pharmaceutical dosage forms
Pavel Matousek, Oxfordshire (GB); Julia Griffen, Cheshire (GB); Andrew Owen, Cheshire (GB); and Lee Dowden, Cheshire (GB)
Assigned to Agilent Technologies LDA UK Limited, Cheshire (GB)
Appl. No. 18/015,007
Filed by Agilent Technologies LDA UK Limited, Chesire (GB)
PCT Filed Jun. 24, 2021, PCT No. PCT/GB2021/051612
§ 371(c)(1), (2) Date Jan. 6, 2023,
PCT Pub. No. WO2022/008875, PCT Pub. Date Jan. 13, 2022.
Claims priority of application No. 2010317 (GB), filed on Jul. 6, 2020.
Prior Publication US 2023/0304935 A1, Sep. 28, 2023
Int. Cl. G01J 3/44 (2006.01); G01N 21/65 (2006.01); G01N 21/95 (2006.01); G01N 33/15 (2006.01)
CPC G01N 21/65 (2013.01) [G01N 21/9508 (2013.01); G01N 33/15 (2013.01); G01N 2201/127 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of Raman spectral analysis of a sample, comprising:
using delivery optics to deliver probe light to a delivery region on the sample;
using collection optics to collect, from a collection region on the sample spaced from the delivery region, said probe light following scattering through the sample;
measuring each of a plurality of target Raman spectral features in the collected light;
determining a spectral distortion of the collected light arising during scattering through the sample; and
quantifying a property of the sample using the target Raman spectral features in combination with the determined spectral distortion, such that the quantified property is compensated for the spectral distortion, wherein quantifying the property of the sample comprises applying the target Raman spectral features to a quantification model which then provides the property of the sample.