US 12,286,458 B2
Binding proteins for the enzyme acid alpha glucosidase (GAA) and uses thereof
Erik Fiedler, Halle/Saale (DE); Mathias Kahl, Halle/Saale (DE); Jonathan Lotze, Halle/Saale (DE); and Eva Bosse-Doenecke, Halle/Saale (DE)
Assigned to Navigo Proteins GmbH, Halle/Saale (DE)
Appl. No. 17/786,885
Filed by Navigo Proteins GmbH, Halle/Saale (DE)
PCT Filed Dec. 17, 2020, PCT No. PCT/EP2020/086701
§ 371(c)(1), (2) Date Jun. 17, 2022,
PCT Pub. No. WO2021/122943, PCT Pub. Date Jun. 24, 2021.
Claims priority of application No. 19217092 (EP), filed on Dec. 17, 2019.
Prior Publication US 2023/0027132 A1, Jan. 26, 2023
Int. Cl. C12N 15/09 (2006.01); C07K 1/22 (2006.01); C07K 14/31 (2006.01); C12N 9/24 (2006.01); C12N 15/10 (2006.01); C12N 15/52 (2006.01); G01N 33/573 (2006.01)
CPC C07K 14/31 (2013.01) [C12N 9/2402 (2013.01); C12Y 302/0102 (2013.01); G01N 33/573 (2013.01); C07K 2319/00 (2013.01); G01N 2333/928 (2013.01)] 15 Claims
 
1. An acid alpha-glucosidase (GAA) binding protein comprising one or more GAA binding domains wherein at least one domain comprises the amino acid sequence of SEQ ID NO: 1 or of SEQ ID NO: 2, or an amino acid sequence with at least 95% sequence identity thereto.