	US 12,286,454 B2
	Irradiation process of pro vitamin D
Anupama Datla, Thane (IN); Prashant Nagre, Thane (IN); Jagdish Tamore, Thane (IN); Sreenath Trivikram, Dombivli (IN); and Sachin Wadhavane, Navi Mumbai (IN)
Assigned to FERMENTA BIOTECH LIMITED, Thane (IN)
Appl. No. 17/609,627
Filed by FERMENTA BIOTECH LIMITED, Thane (IN)
PCT Filed May 11, 2020, PCT No. PCT/IN2020/050426 § 371(c)(1), (2) Date Nov. 8, 2021, PCT Pub. No. WO2020/230159, PCT Pub. Date Nov. 19, 2020.
Claims priority of application No. 201921018751 (IN), filed on May 10, 2019.
Prior Publication US 2022/0234972 A1, Jul. 28, 2022
Int. Cl. C07J 15/00 (2006.01); A61K 31/593 (2006.01); C07C 401/00 (2006.01); C07J 9/00 (2006.01)

CPC C07J 15/005 (2013.01) [A61K 31/593 (2013.01); C07C 401/00 (2013.01); C07J 9/00 (2013.01)]

18 Claims

1. A photochemical process for preparation of vitamin D3, which process comprises;

a) heating a mixture of 7-dehydrocholesterol (7-DHC) and a sterol derivative with catalytic amounts of an anti-oxidant in presence of an alkali in an organic solvent at a temperature range of 20-85° C. to obtain a reaction mass;

b) irradiating the reaction mass using a low pressure Mercury lamp at 10-85° C.; and

c) isolating and purifying vitamin D3 from the irradiated reaction mass,

wherein the sterol derivative is selected from the group consisting of cholesterol, phytosterol, and lanosterol.