	US 12,286,439 B2
	Inhibitors of ERK nuclear translocation
Rony Seger, Rehovot (IL); Karen Flores, Rehovot (IL); Xavier Barril Alonso, Barcelona (ES); and Carlos Galdeano Cantador, Barcelona (ES)
Assigned to Yeda Research and Development Co. Ltd., Rehovot (IL); Universitat de Barcelona, Barcelona (ES); and Institució Catalana de Recerca I Estudis Avançats, Barcelona (ES)
Filed by Yeda Research and Development Co. Ltd., Rehovot (IL); Universitat de Barcelona, Barcelona (ES); and Institució Catalana de Recerca I Estudis Avançats, Barcelona (ES)
Filed on Jun. 3, 2021, as Appl. No. 17/337,570.
Application 17/337,570 is a continuation of application No. PCT/IL2019/051326, filed on Dec. 3, 2019.
Claims priority of provisional application 62/774,360, filed on Dec. 3, 2018.
Prior Publication US 2021/0292338 A1, Sep. 23, 2021
Int. Cl. C07D 498/04 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)

CPC C07D 498/04 (2013.01) [A61K 45/06 (2013.01); A61P 35/00 (2018.01)]

8 Claims

1. A compound represented by Formula I*:

wherein:

the dashed line represents a saturated or unsaturated bond;

R₁is an aryl or heteroaryl, which is substituted by at least two electron withdrawing groups; and

R₂is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, sulfonate, sulfate, cyano, nitro, azide, phosphonyl, phosphinyl, carbonyl, thiocarbonyl, a urea group, a thiourea group, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, C-carboxy, O-carboxy, sulfonamido, guanyl, guanidinyl, hydrazine, hydrazide, thiohydrazide, and amino,

wherein when R₂is hydrogen, the dashed line represents an unsaturated bond,

and wherein R₁is not 2,6-dichlorophenyl.