US 12,285,754 B2
Devices and methods for high-throughput screening of chemical and biochemical compounds
Sungwon Lim, Palo Alto, CA (US); Jun Kim, Mountain View, CA (US); Jamin Koo, Seoul (KR); and Hye-Ryeon Lee, Palo Alto, CA (US)
Assigned to ImpriMed, Inc., Palo Alto, CA (US)
Filed by ImpriMed, Inc., Palo Alto, CA (US)
Filed on Jan. 15, 2020, as Appl. No. 16/744,005.
Application 16/744,005 is a continuation of application No. PCT/US2018/044306, filed on Jul. 30, 2018.
Claims priority of provisional application 62/552,277, filed on Aug. 30, 2017.
Prior Publication US 2020/0147606 A1, May 14, 2020
Int. Cl. B01L 3/00 (2006.01); G01N 33/487 (2006.01); G01N 33/50 (2006.01); G01N 33/00 (2006.01)
CPC B01L 3/5023 (2013.01) [B01L 3/50855 (2013.01); G01N 33/48778 (2013.01); G01N 33/5011 (2013.01); B01L 2300/069 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0832 (2013.01); G01N 33/0081 (2024.05); G01N 2500/10 (2013.01)] 30 Claims
OG exemplary drawing
 
1. An article of manufacture, comprising:
a sheet with an array of distinct and separate regions with respective chemical and/or biochemical compounds located thereon, the array of distinct and separate regions including:
a first region with a first set of one or more chemical and/or biochemical compounds located thereon, wherein the first set of one or more chemical and/or biochemical compounds includes a particular compound;
a second region, that is distinct and separate from the first region, with a second set of one or more chemical and/or biochemical compounds, that is distinct from the first set of one or more chemical and/or biochemical compounds, located thereon, wherein the second set of one or more chemical and/or biochemical compounds does not include the particular compound; and
a third region, that is distinct and separate from the first region and the second region, with a third set of one or more chemical and/or biochemical compounds, that is distinct from the first set of one or more chemical and/or biochemical compounds and the second set of one or more chemical and/or biochemical compounds, located thereon,
wherein:
the sheet defines, for a respective region of the array of distinct and separate regions, one or more through-holes extending from one planar side of the sheet to an opposite planar side of the sheet and one or more connecting regions adjacent to the one or more through-holes so that the respective region is connected to a rest of the sheet by the one or more connecting regions; and
each of the one or more connecting regions has a shape of a spoke connecting the respective region to the rest of the sheet, the one or more connecting regions arranged around the respective region.