US 12,285,627 B2
Fabrication and irradiation of a radioactive isotope skin patch
Frédéric Sarazin, Lakewood, CO (US); Jeramy Zimmerman, Golden, CO (US); Rachel Morneau, Los Alamos, NM (US); Martin Ritter, College Park, MD (US); David Westerly, Aurora, CO (US); and Quentin Diot, Aurora, CO (US)
Assigned to Colorado School of Mines, Golden, CO (US); and The Regents of the University of Colorado, A Body Corporate, Denver, CO (US)
Filed by COLORADO SCHOOL OF MINES, Golden, CO (US); and THE REGENTS OF THE UNIVERSITY OF COLORADO, Denver, CO (US)
Filed on Oct. 18, 2019, as Appl. No. 16/657,717.
Claims priority of provisional application 62/748,135, filed on Oct. 19, 2018.
Prior Publication US 2020/0188691 A1, Jun. 18, 2020
Int. Cl. A61N 5/10 (2006.01); A61K 51/12 (2006.01)
CPC A61N 5/1029 (2013.01) [A61K 51/1279 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A skin patch device for treating a skin condition in a patient comprising:
a substrate layer comprising a substrate material selected for temperature and radiation resistance in an irradiation process;
a foil layer of metal disposed on an area of the substrate layer, comprising an isotope of an element selected from lanthanum, cerium, praseodymium, neodymium,
promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, and lutetium or yttrium,
wherein the foil layer is configured for activation with a neutron flux in the irradiation process to convert the isotope to a radioisotope that emits beta particles during decay, and
wherein the foil layer has a spatially uniform thickness that varies by less than 10% over the area of the foil layer disposed on the substrate layer; and
an encapsulation layer comprising an encapsulation material disposed over the foil layer, wherein the encapsulation material is selected based on temperature and radiation resistance, in the radiation process.