US 12,285,615 B2
Neurostimulation titration process via adaptive parametric modification
Imad Libbus, St. Paul, MN (US); Bruce H. KenKnight, Maple Grove, MN (US); Badri Amurthur, Los Gatos, CA (US); and Scott R. Stubbs, Maple Grove, MN (US)
Assigned to LivaNova USA, Inc., Houston, TX (US)
Filed by LivaNova USA, Inc., Houston, TX (US)
Filed on Dec. 15, 2023, as Appl. No. 18/541,938.
Application 18/541,938 is a continuation of application No. 16/705,043, filed on Dec. 5, 2019, granted, now 11,865,344.
Application 16/705,043 is a continuation of application No. 15/360,188, filed on Nov. 23, 2016, granted, now 10,500,398.
Application 15/360,188 is a continuation of application No. 14/563,181, filed on Dec. 8, 2014, granted, now 9,504,832.
Claims priority of provisional application 62/078,600, filed on Nov. 12, 2014.
Prior Publication US 2024/0108901 A1, Apr. 4, 2024
Int. Cl. A61N 1/36 (2006.01); A61B 5/349 (2021.01); A61B 5/355 (2021.01); A61N 1/05 (2006.01); A61N 1/37 (2006.01); A61N 1/372 (2006.01); G16H 20/30 (2018.01); G16H 20/40 (2018.01); G16H 40/20 (2018.01); G16H 40/63 (2018.01); G16Z 99/00 (2019.01)
CPC A61N 1/36139 (2013.01) [A61B 5/349 (2021.01); A61B 5/355 (2021.01); A61N 1/0551 (2013.01); A61N 1/36114 (2013.01); A61N 1/36132 (2013.01); A61N 1/3615 (2013.01); A61N 1/36167 (2013.01); A61N 1/3702 (2013.01); A61N 1/37223 (2013.01); A61N 1/37235 (2013.01); G16H 20/30 (2018.01); G16H 20/40 (2018.01); G16H 40/20 (2018.01); G16H 40/63 (2018.01); G16Z 99/00 (2019.02)] 20 Claims
OG exemplary drawing
 
1. A method of operating an implantable medical device (IMD) comprising:
delivering neurostimulation to a patient by the IMD, the neurostimulation comprising a plurality of stimulation parameters;
titrating the neurostimulation from an initial intensity toward a target intensity by modifying at least one of the stimulation parameters;
receiving an indication of intolerance to the neurostimulation;
in response to receiving the indication, modifying a first stimulation parameter to decrease an intensity of the neurostimulation;
determining that the first stimulation parameter has reached a maximum modification; and
in response to determining that the first stimulation parameter has reached the maximum modification, modifying a second stimulation parameter to decrease the intensity of the neurostimulation, the second stimulation parameter being different than the first stimulation parameter.