US 12,285,613 B2
Neurostimulation system with neurodegenerative disease detection
Rosana Esteller, Santa Clarita, CA (US); Joseph M. Bocek, Seattle, WA (US); and Sridhar Kothandaraman, Valencia, CA (US)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Jan. 31, 2023, as Appl. No. 18/104,120.
Application 18/104,120 is a continuation of application No. 16/942,314, filed on Jul. 29, 2020, granted, now 11,583,678.
Claims priority of provisional application 62/882,272, filed on Aug. 2, 2019.
Prior Publication US 2023/0166108 A1, Jun. 1, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61B 5/24 (2021.01); A61N 1/04 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36082 (2013.01) [A61B 5/24 (2021.01); A61N 1/0456 (2013.01); A61N 1/0551 (2013.01); A61N 1/36031 (2017.08)] 20 Claims
OG exemplary drawing
 
1. A system for delivering neurostimulation to a patient having a spinal cord using a plurality of electrodes placed over the spinal cord, the system comprising:
a stimulation circuit configured to deliver neurostimulation pulses to the patient using stimulation electrodes selected from the plurality of electrodes; and
a sensing circuit configured to sense an electrospinogram (ESG) signal from the patient using sensing electrodes selected from the plurality of electrodes, the sensing circuit including a signal processing circuit including:
a detection circuit configured to detect a morphology of neural responses from the sensed ESG signal, the neural responses each being a response to the delivery of a pulse of the neurostimulation pulses; and
an analysis circuit configured to analyze the detected morphology of the neural responses for an indication of a neurodegenerative disease.