	US 12,285,540 B2
	Hemostatic composite aggregate materials having surface enriched with hemostatis-promoting agents
Yi-Lan Allen Wang, Somerville, NJ (US); Jerry Yan, Hillsborough, NJ (US); and Leo B. Kriksunov, Ithaca, NY (US)
Assigned to Ethicon, Inc., Raritan, NJ (US)
Filed by Ethicon, Inc., Somerville, NJ (US)
Filed on Jul. 21, 2020, as Appl. No. 16/934,998.
Prior Publication US 2022/0023491 A1, Jan. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 26/00 (2006.01)

CPC A61L 26/0066 (2013.01) [A61L 26/0038 (2013.01); A61L 2420/02 (2013.01)]

9 Claims

1. A hemostatic absorbable composition, comprising:

a flowable plurality of dry separate aggregates each aggregate being an absorbable carrier particle having a first size dimension, that is coated on a surface thereof by a plurality of hemostasis-promoting particles comprising a supplemental hemostasis promoting agent, having a size dimension smaller than the first size dimension, wherein the supplemental hemostasis-promoting agent comprises oxidized regenerated cellulose (ORC) and the absorbable carrier particles comprise gelatin, wherein a mass ratio of ORC: gelatin is greater than 10:1.