US 12,285,526 B2
Nanoparticle composition with reduced contaminant and production method thereof
Hironori Tanaka, Hyogo (JP); Yuya Ochii, Hyogo (JP); and Tetsuharu Ibaraki, Hiroshima (JP)
Assigned to SHIONOGI & CO., LTD., Osaka (JP); and HIROSHIMA METAL & MACHINERY CO., LTD., Tokyo (JP)
Appl. No. 17/434,883
Filed by Shionogi & Co., Ltd., Osaka (JP); and HIROSHIMA METAL & MACHINERY CO., LTD., Tokyo (JP)
PCT Filed Feb. 28, 2020, PCT No. PCT/JP2020/008441
§ 371(c)(1), (2) Date Aug. 30, 2021,
PCT Pub. No. WO2020/179701, PCT Pub. Date Sep. 10, 2020.
Claims priority of application No. 2019-037358 (JP), filed on Mar. 1, 2019.
Prior Publication US 2022/0160634 A1, May 26, 2022
Int. Cl. A61K 9/14 (2006.01); B02C 17/20 (2006.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01)
CPC A61K 9/14 (2013.01) [B02C 17/20 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method for the production of fine particles via a grinding process using a bead mill,
wherein the method comprises:
a) a step of preparing a slurry comprising a material to be ground and a dispersion medium,
b) a step of adjusting the pH of the slurry prepared in the step a) to 6.5 to 9, and
c) a step of agitating the slurry prepared in the step b) and beads in the bead mill; or
wherein the method comprises:
a′) a step of preparing a slurry comprising a material to be ground, beads and a dispersion medium,
b′) a step of adjusting the pH of the slurry prepared in the step a′) to 6.5 to 9, and
c′) a step of agitating the slurry prepared in the step b′) in the bead mill;
wherein the material to be ground is a pharmaceutical compound, wherein impurities caused by the grinding process are derived from the beads and/or the bead mill, and wherein an amount of the impurities is less than 50 ppm with respect to the weight of the material to be ground.