US 12,285,525 B2
Compound or salt thereof and lipid particles
Shintaro Tanabe, Ashigarakami-gun (JP); Masahiko Yamamoto, Ashigarakami-gun (JP); Kimihiko Sato, Ashigarakami-gun (JP); Motomasa Takahashi, Ashigarakami-gun (JP); Kazuhiro Tsuna, Ashigarakami-gun (JP); Yasutaka Tasaki, Ashigarakami-gun (JP); Taisuke Endo, Ashigarakami-gun (JP); Issei Doi, Ashigarakami-gun (JP); and Hirofumi Fukunaga, Ashigarakami-gun (JP)
Assigned to FUJIFILM Corporation, Tokyo (JP)
Filed by FUJIFILM Corporation, Tokyo (JP)
Filed on Dec. 4, 2020, as Appl. No. 17/112,239.
Application 17/112,239 is a continuation of application No. PCT/JP2019/022833, filed on Jun. 7, 2019.
Claims priority of application No. 2018-110709 (JP), filed on Jun. 8, 2018.
Prior Publication US 2021/0085604 A1, Mar. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/127 (2006.01); A61K 9/1272 (2025.01); A61K 9/1278 (2025.01); C07C 219/06 (2006.01); C12N 15/88 (2006.01)
CPC A61K 9/1272 (2013.01) [A61K 9/1278 (2013.01); C07C 219/06 (2013.01); C12N 15/88 (2013.01)] 21 Claims
 
1. A compound represented by Formula (1) or a salt thereof,

OG Complex Work Unit Chemistry
wherein in the formula, X represents —NR1— or —O—,
R1 represents a hydrogen atom, a hydrocarbon group having 6 to 24 carbon atoms, or a group represented by R21-L1-R22—, R21 represents a hydrocarbon group having 1 to 24 carbon atoms, L1 represents —O(CO)O—, —O(CO)—, —(CO)O—, —O—, or a group represented by the following formula,

OG Complex Work Unit Chemistry
R22 represents a divalent hydrocarbon linking group having 1 to 18 carbon atoms,
R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group having 3 to 24 carbon atoms, or a group represented by R31-L2-R32—, R31 represents a hydrocarbon group having 1 to 24 carbon atoms, L2 represents —O(CO)O—, —O(CO)—, —(CO)O—, —O—, or a group represented by the following formula,

OG Complex Work Unit Chemistry
R32 represents a divalent hydrocarbon linking group having 1 to 18 carbon atoms,
R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group having 1 to 18 carbon atoms that may be substituted,
a substituent on the alkyl group having 1 to 18 carbon atoms that may be substituted is a hydroxyl group, a carboxyl group, an amino group represented by —NR45R46, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or a group represented by —O(CO)O—R41, —O(CO)—R42, —(CO)O—R43, or —O—R44, R41, R42, R43, R44, R45, and R46 each independently represent a hydrocarbon group having 1 to 18 carbon atoms,
a substituent on the substituted or unsubstituted aryl group and on the substituted or unsubstituted heteroaryl group is an alkyl group having 1 to 18 carbon atoms, a hydroxyl group, a carboxyl group, an amino group represented by —NR45R46, or a group represented by —O(CO)O—R41, —O(CO)—R42, —(CO)O—R43, or —O—R44, R41, R42, R43, R44, R45, and R46 each independently represent a hydrocarbon group having 1 to 18 carbon atoms,
a, b, c, and d each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.