US 12,285,477 B2
Polynucleotide molecules used for the prevention or treatment of HPV infection related diseases
Shan Cen, Suzhou (CN); Jing Wang, Suzhou (CN); Weiguo Zhang, Suzhou (CN); and Yijie Dong, Suzhou (CN)
Assigned to RINUAGENE BIOTECHNOLOGY CO., LTD., Suzhou (CN); and RINUAGENE INTERNATIONAL HK LIMITED, Hong Kong (CN)
Filed by RINUAGENE BIOTECHNOLOGY CO., LTD., Jiangsu (CN); and RINUAGENE INTERNATIONAL HK LIMITED, Kowloon (CN)
Filed on Jul. 11, 2024, as Appl. No. 18/770,056.
Application 18/770,056 is a continuation of application No. PCT/CN2023/142229, filed on Dec. 27, 2023.
Claims priority of application No. PCT/CN2022/143328 (WO), filed on Dec. 29, 2022; application No. 202311684185.8 (CN), filed on Dec. 8, 2023; and application No. PCT/CN2023/114487 (WO), filed on Dec. 8, 2023.
Prior Publication US 2024/0358814 A1, Oct. 31, 2024
Int. Cl. A61K 39/12 (2006.01); A61K 9/51 (2006.01); A61K 39/39 (2006.01); A61K 39/395 (2006.01); A61P 31/20 (2006.01); A61P 35/00 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/12 (2013.01) [A61K 9/5123 (2013.01); A61K 39/39 (2013.01); A61K 39/3955 (2013.01); A61P 31/20 (2018.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55516 (2013.01); C07K 2319/02 (2013.01); C12N 2710/20022 (2013.01); C12N 2710/20034 (2013.01)] 25 Claims
 
1. A polynucleotide molecule, comprising at least a coding sequence of an HPV antigen polypeptide, the antigen polypeptide sequentially from the N-terminus to the C-terminus comprises at least:
an amino acid sequence C, an amino acid sequence B, and an amino acid sequence A;
wherein,
the amino acid sequence A sequentially from the N-terminus to the C-terminus comprises at least SEQ ID NOs: 1-4, and each of the amino acid sequences represented by the SEQ ID NOs is connected directly and sequentially or by a linker sequentially;
the amino acid sequence B sequentially from the N-terminus to the C-terminus comprises at least SEQ ID NOs: 5-8, and each of the amino acid sequences represented by the SEQ ID NOs is connected directly and sequentially or by a linker sequentially; and
the amino acid sequence C comprises an HPV E2 antigen sequence.