	US 12,285,459 B2
	Saposin-A derived peptides and uses thereof
Randolph S. Watnick, Newton, MA (US)
Assigned to CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US)
Filed by CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US)
Filed on Jan. 31, 2023, as Appl. No. 18/103,740.
Application 18/103,740 is a division of application No. 16/511,935, filed on Jul. 15, 2019, granted, now 11,590,196.
Application 16/511,935 is a division of application No. 14/367,577, granted, now 10,736,935, issued on Aug. 11, 2020, previously published as PCT/US2012/071424, filed on Dec. 21, 2012.
Claims priority of provisional application 61/579,095, filed on Dec. 22, 2011.
Prior Publication US 2023/0285501 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/08 (2019.01); A61K 38/00 (2006.01); A61K 38/07 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 5/11 (2006.01); C07K 5/113 (2006.01); C07K 7/06 (2006.01); C07K 14/475 (2006.01); C07K 16/00 (2006.01); C12Q 1/6886 (2018.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01); G01N 33/74 (2006.01)

CPC A61K 38/08 (2013.01) [A61K 38/07 (2013.01); A61K 39/39591 (2013.01); A61K 45/06 (2013.01); C07K 5/1019 (2013.01); C07K 5/1021 (2013.01); C07K 7/06 (2013.01); C07K 14/475 (2013.01); C07K 16/00 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5023 (2013.01); G01N 33/574 (2013.01); G01N 33/6893 (2013.01); G01N 33/74 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C12Q 2600/106 (2013.01); G01N 2800/52 (2013.01)]

9 Claims

1. A method of inhibiting angiogenesis in a subject in need thereof, the method comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising an isolated peptide consisting of an amino acid sequence selected from the group consisting of CDWLPK (SEQ ID NO: 3) and DWLPK (SEQ ID NO: 4), wherein the peptide is acylated, carboxyamidated, pegylated, or conjugated to a polymer that enhances serum half-life of the peptide.