US 12,285,449 B2
Fermented milk for improving autonomic nervous function
Yasuyoshi Watanabe, Osaka (JP); Kei Mizuno, Osaka (JP); Jun Henmi, Tokyo (JP); Seiya Makino, Tokyo (JP); and Hiroshi Kano, Tokyo (JP)
Assigned to MEIJI CO., LTD, Tokyo (JP); and UNIVERSITY PUBLIC CORPORATION OSAKA, Osaka (JP)
Filed by MEIJI CO., LTD., Tokyo (JP); and University Public Corporation Osaka, Osaka (JP)
Filed on May 31, 2022, as Appl. No. 17/828,772.
Application 17/828,772 is a continuation of application No. 16/864,486, filed on May 1, 2020, abandoned.
Claims priority of application No. 2019-090381 (JP), filed on May 13, 2019.
Prior Publication US 2022/0288140 A1, Sep. 15, 2022
Int. Cl. A61K 35/747 (2015.01); A61K 35/20 (2006.01); A61P 25/28 (2006.01)
CPC A61K 35/747 (2013.01) [A61K 35/20 (2013.01); A61P 25/28 (2018.01)] 8 Claims
 
1. A method of reducing a relative sympathetic nerve activity index comprising:
administering 80 g/dose to 150 g/dose or 80 mL/dose to 150 mL/dose of a fermented milk comprising Lactobacillus delbrueckii subsp. bulgaricus and its metabolite, and 7.0% to 9.0% of non-fat milk solid content, twice per day for 4 weeks or longer, to a subject in need thereof,
wherein the method is effective for reducing the relative sympathetic nerve activity index beginning at least 4 weeks from the administration of the fermented milk.