US 12,285,423 B2
Composition for enhancing mitochondrial function
Larisa Andreeva, London (GB); Igor Anatolievich Pomytkin, Moscow (RU); and Galina Nonina Skladtchikova, Hellemp (DK)
Assigned to Mitocholine Ltd., London (GB)
Filed by MITOCHOLINE LTD, London (GB)
Filed on Oct. 23, 2023, as Appl. No. 18/382,904.
Application 18/382,904 is a continuation of application No. 18/051,460, filed on Oct. 31, 2022, granted, now 11,826,362.
Application 18/051,460 is a continuation of application No. 16/624,830, granted, now 11,571,415, issued on Feb. 7, 2023, previously published as PCT/GB2018/051797, filed on Jun. 27, 2018.
Claims priority of application No. 1710316 (GB), filed on Jun. 28, 2017; application No. 1715214 (GB), filed on Sep. 20, 2017; application No. 1800244 (GB), filed on Jan. 8, 2018; and application No. 1807733 (GB), filed on May 12, 2018.
Prior Publication US 2024/0066019 A1, Feb. 29, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/455 (2006.01); A23L 33/13 (2016.01); A23L 33/15 (2016.01); A23L 33/17 (2016.01); A61K 31/194 (2006.01); A61K 31/197 (2006.01); A61K 31/706 (2006.01); A61K 47/16 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01)
CPC A61K 31/455 (2013.01) [A23L 33/13 (2016.08); A23L 33/15 (2016.08); A23L 33/17 (2016.08); A61K 31/194 (2013.01); A61K 31/197 (2013.01); A61K 31/706 (2013.01); A61K 47/16 (2013.01); A61P 25/24 (2018.01); A61P 25/28 (2018.01)] 12 Claims
 
1. A method for enhancing synthesis of adenosine triphosphate (ATP) in mitochondria of brain cells of a healthy human subject; the method comprising:
providing for oral consumption by the human subject, a nutritional composition comprising a synergistic compound of choline cation and succinate anion (2-) in a molar ratio of choline: succinate of 2:1 in the form of dicholine succinate (DiSu), wherein the composition is formulated to comprise a daily dosage of DiSu that synergistically increases ATP levels in the brain cells, wherein:
the daily dosage of the DiSu is within a range of from about 250 mg to about 2000 mg; and
the synergistic increase in ATP levels in the brain cells is relative to the sum of increases in ATP levels from choline cation and succinate anion (2-) not combined together in the molar ratio of choline: succinate of 2:1 in the form of dicholine succinate (DiSu).