US 12,285,416 B2
Compositions and methods for reducing muscle contraction
Brian L. Burback, Hilliard, OH (US); Jessica Catherine Bright, Dublin, OH (US); and Jerry D. Johnson, Dublin, OH (US)
Assigned to Battelle Memorial Institute, Columbus, OH (US)
Filed by Battelle Memorial Institute, Columbus, OH (US); and Jessica Catherine Bright, Dublin (IE)
Filed on Jun. 21, 2022, as Appl. No. 17/845,905.
Application 17/845,905 is a continuation of application No. 16/695,306, filed on Nov. 26, 2019, granted, now 11,382,906.
Application 16/695,306 is a continuation of application No. 15/885,987, filed on Feb. 1, 2018, granted, now 10,702,510, issued on Jul. 7, 2020.
Claims priority of provisional application 62/453,582, filed on Feb. 2, 2017.
Prior Publication US 2023/0054382 A1, Feb. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/444 (2006.01); A61J 1/14 (2023.01); A61K 9/00 (2006.01); A61K 31/15 (2006.01); A61K 31/4425 (2006.01); A61K 45/06 (2006.01); A61P 21/02 (2006.01); A61P 41/00 (2006.01); A61P 43/00 (2006.01)
CPC A61K 31/444 (2013.01) [A61J 1/14 (2013.01); A61K 9/0019 (2013.01); A61K 31/15 (2013.01); A61K 31/4425 (2013.01); A61K 45/06 (2013.01); A61P 21/02 (2018.01); A61P 41/00 (2018.01); A61P 43/00 (2018.01); A61J 2205/30 (2013.01)] 17 Claims
 
1. A method of performing a surgical procedure, comprising:
administering an oxime or pharmaceutically acceptable salt thereof, and an anesthetic, to an individual, wherein said oxime or pharmaceutically acceptable salt thereof is administered in an amount that achieves a reduction of muscle contraction.
 
5. The method of claim 1, wherein said oxime or pharmaceutically acceptable salt thereof is selected from one or more of

OG Complex Work Unit Chemistry