US 12,285,331 B2
Systems, devices, and methods relating to the manufacture of implantable prosthetic valves
Garrett Johnson, Costa Mesa, CA (US); Jason G. Beith, Santa Ana, CA (US); Marek Lhotak, Irvine, CA (US); Praveen De Silva, Irvine, CA (US); Peter Millson, Salt Lake City, UT (US); Francis P. Maguire, Salt Lake City, UT (US); and Morteza Gharib, Altadena, CA (US)
Assigned to Foldax, Inc., Salt Lake City, UT (US); and California Institute of Technology, Pasadena, CA (US)
Filed by Foldax, Inc., Salt Lake City, UT (US); and California Institute of Technology, Pasadena, CA (US)
Filed on Mar. 16, 2020, as Appl. No. 16/820,274.
Claims priority of provisional application 62/904,496, filed on Sep. 23, 2019.
Claims priority of provisional application 62/819,839, filed on Mar. 18, 2019.
Prior Publication US 2021/0038379 A1, Feb. 11, 2021
Int. Cl. A61F 2/24 (2006.01); A61L 27/18 (2006.01); C08G 18/61 (2006.01)
CPC A61F 2/2418 (2013.01) [A61F 2/2415 (2013.01); A61L 27/18 (2013.01); C08G 18/61 (2013.01); A61F 2240/004 (2013.01); A61L 2430/20 (2013.01)] 17 Claims
OG exemplary drawing
 
1. An implantable prosthetic heart valve, comprising:
an expandable support structure comprising a frame having a plurality of deflectable struts forming multiple rows of cells interconnected in a lattice, an upstream end embedded in polymer, a downstream end embedded in polymer, wherein the interconnected cells in the lattice form a continuous edge along the multiple rows of cells interconnected in the lattice and angled between the upstream end the downstream end, and an electrospun polymer sealed about a periphery of the support structure; and
a polymeric valvular body comprising a plurality of artificial leaflets formed from a cured polymer, coupled with and contoured to the frame between the upstream end embedded in polymer and the downstream end embedded in polymer and, encapsulating the lattice in the cured polymer and wherein the downstream ends of the leaflets engage the continuous edge along a length thereof;
wherein the frame defines a plurality of commissure positions and a plurality of deflectable struts at the downstream end forming a crest offset from the plurality of commissure positions,
wherein the electrospun polymer of the support structure comprises a skirt located upstream from an upstream end of the frame; and
wherein the skirt has an outflow edge portion that is fused to the polymer in which the upstream end is embedded.