US 11,963,768 B2
Methods, systems, and devices for calibration and optimization of glucose sensors and sensor output
Keith Nogueira, Mission Hills, CA (US); Peter Ajemba, Canyon Country, CA (US); Michael E. Miller, Culver City, CA (US); Steven C. Jacks, Culver City, CA (US); Jeffrey Nishida, Redwood City, CA (US); Andy Y. Tsai, Pasadena, CA (US); and Andrea Varsavsky, Santa Monica, CA (US)
Assigned to MEDTRONIC MINIMED, INC., Northridge, CA (US)
Filed by Medtronic MiniMed, Inc., Northridge, CA (US)
Filed on May 5, 2022, as Appl. No. 17/737,236.
Application 17/737,236 is a continuation of application No. 16/117,733, filed on Aug. 30, 2018, granted, now 11,344,235.
Claims priority of provisional application 62/558,248, filed on Sep. 13, 2017.
Prior Publication US 2022/0273198 A1, Sep. 1, 2022
Int. Cl. A61B 5/1495 (2006.01); A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/021 (2006.01); A61B 5/024 (2006.01); A61B 5/11 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61B 5/1468 (2006.01); A61B 5/1486 (2006.01); G01N 27/02 (2006.01); G06N 5/022 (2023.01); G16H 20/17 (2018.01); G16H 40/40 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01)
CPC A61B 5/1495 (2013.01) [A61B 5/14532 (2013.01); A61B 5/1468 (2013.01); A61B 5/14865 (2013.01); A61B 5/6849 (2013.01); A61B 5/686 (2013.01); G01N 27/026 (2013.01); G06N 5/022 (2013.01); G16H 20/17 (2018.01); G16H 40/40 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01); A61B 5/0075 (2013.01); A61B 5/02055 (2013.01); A61B 5/021 (2013.01); A61B 5/024 (2013.01); A61B 5/1118 (2013.01); A61B 5/14546 (2013.01); A61B 5/1455 (2013.01); A61B 5/7203 (2013.01); A61B 5/7221 (2013.01); A61B 5/7267 (2013.01); A61B 5/742 (2013.01); A61B 2505/07 (2013.01); A61B 2560/0223 (2013.01); A61B 2560/0252 (2013.01); A61B 2560/0257 (2013.01); A61B 2562/028 (2013.01); A61B 2562/029 (2013.01); A61B 2562/164 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for calibrating a glucose sensor, the method comprising:
performing a perturbation analysis for a plurality of sensor characteristic features of the glucose sensor, the perturbation analysis performed for each sensor characteristic feature of the plurality of sensor characteristic features by:
accessing a respective sensor characteristic feature signal,
determining a respective sensor glucose value based on the respective sensor characteristic feature signal,
determining a respective plurality of changes in the sensor glucose value based on adding a respective plurality of noise perturbations to the respective sensor characteristic feature signal, and
generating a respective perturbation response for the respective sensor characteristic feature, the respective perturbation response plotting degrees of change in the respective sensor characteristic feature, caused by the respective plurality of noise perturbations, against degrees of change in respective sensor glucose value, corresponding to the respective plurality of changes in the sensor glucose value;
selecting one or more sensor characteristic features from the plurality of sensor characteristic features based on the perturbation responses for the plurality of sensor characteristic features and based on a threshold value; and
calibrating the glucose sensor based on the selected one or more sensor characteristic features.